Anti-Human Synaptophysin eFluor® 615

Description: This EP10 monoclonal antibody reacts with human Synaptophysin, which is also known as Major Synaptic Vesicle Protein p38. This 38-kDa integral membrane protein is expressed on neuronal presynaptic vesicles in the brain, spinal cord, retina, neuromuscular junctions, and adrenal medulla. Synaptophysin is also expressed in neuroendocrine tumors and neuroblastomas. Synaptophysin has been reported to play a role in synaptic vesicle trafficking. EP10 also recognizes hamster synaptophysin.

References: Arthur CP, Stowell MH. Structure of synaptophysin: a hexameric MARVEL-domain channel protein. Structure. 2007 Jun;15(6):707-14.

Honer WG, Kaufmann CA, Davies P. Characterization of a synaptic antigen of interest in neuropsychiatric illness. Biol Psychiatry. 1992 Jan 15;31(2):147-58. (EP10, ICC)

Südhof TC, Lottspeich F, Greengard P, Mehl E, Jahn R. A synaptic vesicle protein with a novel cytoplasmic domain and four transmembrane regions. Science. 1987 Nov 20;238(4830):1142-4.

Wiedenmann B, Franke WW. Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles. Cell. 1985 Jul;41(3):1017-28.