Human sVAP-1 Platinum ELISA

Description: The human sVAP-1 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human sVAP-1. The human sVAP-1 ELISA is for research use only. Not for diagnostic or therapeutic procedures.

Lymphocyte binding to vascular endothelium is a prerequisite for the move- ment of immune cells from the blood into lymphoid tissues and into sites of inflammation. Under inflammatory conditions, cell surface expression of VAP-1 (vascular adhesion protein-1) which is an endothelial sialoglycoprotein, is induced. VAP-1 is a type II transmembrane protein of 84.6 kDa with a single transmembrane domain and N and O-glycosylation sites in the extracellular domain. In vivo, VAP-1 exists predominantly as a 180 kDa homodimer and functions both as an enzyme (monoamine oxidase) and an adhesion molecule for lymphocytes.

A circulating form of human Vascular Adhesion Protein-1 (sVAP-1) has been characterized. This sVAP-1 has been shown to be elevated in sera of patients with certain liver diseases and a correlation with the diagnosis of the patients was demonstrated.

Citations: Li,H.Y.; Lee,W.J.; Chen,M.J.; Chuang,L.M.. Change in vascular adhesion protein-1 and metabolic phenotypes after vertical banded gastroplasty for morbid obesity. Obes.Res 2005;13:855-861. (Link)

Visentin,V.; Prevot,D.; De,Saint Front,V; Morin-Cussac,N.; Thalamas,C.; Galitzky,J.; Valet,P.; Zorzano,A.; Carpene,C.. Alteration of amine oxidase activity in the adipose tissue of obese subjects. Obes.Res 2004;12:547-555. (Link)

References: Kurkijarvi,R.; Adams,D.H.; Leino,R.; Mottonen,T.; Jalkanen,S.; Salmi,M.. Circulating form of human vascular adhesion protein-1 (VAP-1): increased serum levels in inflammatory liver diseases. J.Immunol. 1998;161:1549-1557. (Link)

Salmi,M.; Jalkanen,S.. Different forms of human vascular adhesion protein-1 (VAP-1) in blood vessels in vivo and in cultured endothelial cells: implications for lymphocyte-endothelial cell adhesion models. Eur.J.Immunol. 1995;25:2803-2812. (Link)

Salmi,M.; Rajala,P.; Jalkanen,S.. Homing of mucosal leukocytes to joints. Distinct endothelial ligands in synovium mediate leukocyte-subtype specific adhesion 107. J.Clin.Invest 1997;99:2165-2172. (Link)

Arvilommi,A.M.; Salmi,M.; Jalkanen,S.. Organ-selective regulation of vascular adhesion protein-1 expression in man. Eur.J.Immunol. 1997;27:1794-1800. (Link)

Jalkanen,S.; Salmi,M.. Vascular adhesion protein-1 (VAP-1)--a new adhesion molecule recruiting lymphocytes to sites of inflammation. Res.Immunol. 1993;144:746-749. (Link)

Salmi,M.; Tohka,S.; Berg,E.L.; Butcher,E.C.; Jalkanen,S.. Vascular adhesion protein 1 (VAP-1) mediates lymphocyte subtype-specific, selectin-independent recognition of vascular endothelium in human lymph nodes. J.Exp.Med. 1997;186:589-600. (Link)

Salmi,M.; Kalimo,K.; Jalkanen,S.. Induction and function of vascular adhesion protein-1 at sites of inflammation. J.Exp.Med. 1993;178:2255-2260. (Link)