Human sCD86 Instant ELISA

Description: The human sCD86 Instant ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human sCD86. The human sCD86 Instant ELISA is for research use only. Not for diagnostic or therapeutic procedures

CD86, like CD80, is a cell surface molecule found only on antigen-presenting cells, and is required for activation of CD4-positive T-cells by the interaction with CD28 and cytotoxic T-lymphocyte-asociated antigen 4 (CTLA-4) on T-cells. It mediates critical T-cell inhibitory signals. CD80 and CD86 are type I glycoproteins, and are made up of two extracellular lg-like domains, a transmembrane region and a cytoplasmic tail. The N-terminal V-domain and membrane proximal C-domain share homology with the variable region and constant region of lg respectively. CD86 was found to play an important role in immune tolerance and associated dysregulations like found in autoimmune diseases, such as multiple scleroses, systemic lupus erythematosus, and in graft acceptance.

Citations: Wong,C.K.; Ho,A.W.; Tong,P.C.; Yeung,C.Y.; Chan,J.C.; Kong,A.P.; Lam,C.W.. Aberrant expression of soluble co-stimulatory molecules and adhesion molecules in type 2 diabetic patients with nephropathy. J Clin Immunol 2008;28:36-43. (Link)

Ip,W.K; Wong,C.K.; Leung,T.F.; Lam,C.W.K. Elevation of Plasma Soluble T Cell Costimulatory Molecules CTLA-4, CD28 and CD80 in Children with Allergic Asthma. International Archives of Allergy and Immunology 2005;137:45-52. (Link)

Wong,C.K.; Lit,L.C.W.; Tam,L.S.; Li,E.K.; Lam,C.W.K.. Aberrant production of soluble costimulatory molecules CTLA-4, CD28, CD80 and CD86 in patients with systemic lupus erythematosus. Rheumatology 2005;44:keh663(Link)

Wong,C.K.; Lun,S.W.M.; Ko,F.W.S.; Ip,W.K.; Hui,D.S.C.; Lam,C.W.K.. Increased expression of plasma and cell surface co-stimulatory molecules CTLA-4, CD28 and CD86 in adult patients with allergic asthma. Clinical and Experimental Immunology 2005;141:122-129. (Link)

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Wu,Q.; Jinde,K.; Endoh,M.; Sakai,H.. Costimulatory molecules CD80 and CD86 in human crescentic glomerulonephritis. Am.J.Kidney Dis. 2003;41:950-961. (Link)

Nagafuchi,H.; Shimoyama,Y.; Kashiwakura,J.; Takeno,M.; Sakane,T.; Suzuki,N.. Preferential expression of B7.2 (CD86), but not B7.1 (CD80), on B cells induced by CD40/CD40L interaction is essential for anti-DNA autoantibody production in patients with systemic lupus erythematosus. Clin.Exp.Rheumatol. 2003;21:71-77. (Link)

Sansom,D.M.; Manzotti,C.N.; Zheng,Y.. What's the difference between CD80 and CD86?. Trends Immunol. 2003;24:314-319. (Link)

Rogers,N.J.; Jackson,I.M.; Jordan,W.J.; Hawadle,M.A.; Dorling,A.; Lechler,R.I.. Cross-species costimulation: relative contributions of CD80, CD86, and CD40. Transplantation 2003;75:2068-2076. (Link)

Takasaki,Y.; Abe,K.; Tokano,Y.; Hashimoto,H.. The expression of LFA-1, ICAM-1, CD80 and CD86 molecules in lupus patients: implication for immunotherapy. Intern.Med. 1999;38:175-177. (Link)

Lane,P.. Regulation of T and B cell responses by modulating interactions between CD28/CTLA4 and their ligands, CD80 and CD86 75. Ann.N.Y.Acad.Sci. 1997;815:392-400. (Link)

Vasu,C.; Wang,A.; Gorla,S.R.; Kaithamana,S.; Prabhakar,B.S.; Holterman,M.J.. CD80 and CD86 C domains play an important role in receptor binding and co-stimulatory properties. Int.Immunol. 2003;15:167-175. (Link)

Filion,L.G.; Matusevicius,D.; Graziani-Bowering,G.M.; Kumar,A.; Freedman,M.S.. Monocyte-derived IL12, CD86 (B7-2) and CD40L expression in relapsing and progressive multiple sclerosis. Clin.Immunol. 2003;106:127-138. (Link)

Jonker,M.; Ossevoort And MA; Vierboom,M.. Blocking the CD80 and CD86 costimulation molecules: lessons to be learned from animal models 54. Transplantation 2002;73:S23-S26. (Link)

Lu,P.; Wang,Y.L.; Linsley,P.S.. Regulation of self-tolerance by CD80/CD86 interactions. Curr.Opin.Immunol. 1997;9:858-862. (Link)