Human sCD40L Platinum ELISA

Description: The human sCD40L ELISA (extra sensitive) is an enzyme-linked immunosorbent assay for the quantitative detection of human sCD40L. The human sCD40L ELISA (extra sensitive) is for in vitro diagnostic use. Not for use in therapeutic procedures.

CD40 belongs to the TNF receptor superfamily and is a biochemical marker for the identification of activated platelets of patients with cardiovascular diseases (angina pectoris, infarction, stroke etc.)

A key role of CD40/CD40ligand interactions in immune activation, particularly in T-cell dependent B cell responses is anticipated. CD40 Ligand is expressed on the surface of activated CD4+ T cells, basophils, and mast cells. Binding of CD40L to its receptor, CD40, on the surface of B cells stimulates B-cell proliferation, adhesion and differentiation. A soluble isoform of CD40L has been shown to exist in the circulation. This soluble molecule is a homotrimer of a 18kDa protein exhibiting full activity in B cell proliferation and differentiation assays, is able to rescue B cells from apoptosis and binds soluble CD40.

CD40L is discussed in relation to a potential role in supporting B cell tumors and it has been discovered that the molecular defect in the X-linked Hyper-IgM-Syndrome is targeted to the CD40 L gene, it is functional involved in B cell hybridomas and chronic lymphocytic leukemia as well as several autoimmune diseases.

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Yan,J.C.; Zhu,J.; Gao,L.; Wu,Z.G.; Kong,X.T.; Zong,R.Q.; Zhan,L.Z.. The effect of elevated serum soluble CD40 ligand on the prognostic value in patients with acute coronary syndromes. Clinica Chimica Acta 2004;343:155-159. (Link)

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Hammett,Christopher J.K.; Prapavessis,Harry; Baldi,J.Chris; Varo,Nerea; Schoenbeck,Uwe; Ameratunga,Rohan; French,John K.; White,Harvey D.; Stewart,Ralph A.H.. Effects of exercise training on 5 inflammatory markers associated with cardiovascular risk. American Heart Journal 2006;151:(Link)

Sipsas,Nikolaos V.; Sfikakis,Petros P.; Kontos,Athanasios; Kordossis,Theodore. Levels of Soluble CD40 Ligand (CD154) in Serum Are Increased in Human Immunodeficiency Virus Type 1-Infected Patients and Correlate with CD4+ T-Cell Counts. Clinical and Diagnostic Laboratory Immunology 2002;9:558-561. (Link)

Schonbeck,Uwe; Varo,Nerea; Libby,Peter; Buring,Julie; Ridker,Paul M.. Soluble CD40L and Cardiovascular Risk in Women. Circulation 2001;104:2266-2268. (Link)

Varo,Nerea; de Lemos,James A.; Libby,Peter; Morrow,David A.; Murphy,Sabina A.; Nuzzo,Rebecca; Gibson,C.Michael; Cannon,Christopher P.; Braunwald,Eugene; Schonbeck,Uwe. Soluble CD40L: Risk Prediction After Acute Coronary Syndromes459. Circulation 2003;108:1049-1052. (Link)

Jinnin,M.; Ihn,H.; Yazawa,N.; Asano,Y.; Yamane,K.; Tamaki,K.. Circulating soluble CD40 ligand in patients with eosinophilic fasciitis. Annals of the Rheumatic Diseases 2003;62:190-191. (Link)

Solanilla,Anne; Dechanet,Julie; El Andaloussi,Abdel; Dupouy,Moryse; Godard,Francois; Chabrol,Jerome; Charbord,Pierre; Reiffers,Josy; Nurden,Alan T.; Weksler,Babette; Moreau,Jean Francois; Ripoche,Jean. CD40-ligand stimulates myelopoiesis by regulating flt3-ligand and thrombopoietin production in bone marrow stromal cells. Blood 2000;95:3758-3764. (Link)

Garlichs,C.D.; Eskafi,S.; Raaz,D.; Schmidt,A.; Ludwig,J.; Herrmann,M.; Klinghammer,L.; Daniel,W.G.; Schmeisser,A.. Patients with acute coronary syndromes express enhanced CD40 ligand/CD154 on platelets. Heart 2001;86:649-655. (Link)

Jinchuan,Y.; Zonggui,W.; Jinming,C.; Li,L.; Xiantao,K.. Upregulation of CD40-CD40 ligand system in patients with diabetes mellitus. Clinica Chimica Acta 2004;339:85-90. (Link)

Czapiga,M.; Kirk,A.D.; Lekstrom-Himes,J.. Platelets deliver costimulatory signals to antigen-presenting cells: A potential bridge between injury and immune... Experimental Hematology 2004;32:135-139. (Link)

Cipollone,Francesco; Mezzetti,Andrea; Porreca,Ettore; Di Febbo,Concetta; Nutini,Michele; Fazia,Maria; Falco,Angela; Cuccurullo,Franco; Davi,Giovanni. Association Between Enhanced Soluble CD40L and Prothrombotic State in Hypercholesterolemia: Effects of Statin Therapy. Circulation 2002;106:399-402. (Link)

Garlichs,C.D.; Kozina,S.; Fateh-Moghadam,S.; Tomandl,B.; Stumpf,C.; Eskafi,S.; Raaz,D.; Schmeisser,A.; Yilmaz,A.; Ludwig,J.; Neundorfer,B.; Daniel,W.G.. Upregulation of CD40-CD40 Ligand (CD154) in Patients With Acute Cerebral Ischemia. Stroke 2003;34:1412-1418. (Link)

Viallard,Jean Francois; Solanilla,Anne; Gauthier,Bruno; Contin,Cecile; Dechanet,Julie; Grosset,Christophe; Moreau,Jean Francois; Praloran,Vincent; Nurden,Paquita; Pellegrin,Jean Luc; Nurden,Alan T.; Ripoche,Jean. Increased soluble and platelet-associated CD40 ligand in essential thrombocythemia and reactive thrombocytosis. Blood 2002;99:2612-2614. (Link)

Aukrust,Pal; Muller,Fredrik; Ueland,Thor; Berget,Trude; Aaser,Elinor; Brunsvig,Anne; Solum,Nils Olav; Forfang,Kolbjorn; Froland,Stig S.; Gullestad,Lars. Enhanced Levels of Soluble and Membrane-Bound CD40 Ligand in Patients With Unstable Angina : Possible Reflection of T Lymphocyte and Platelet Involvement in the Pathogenesis of Acute Coronary Syndromes. Circulation 1999;100:614-620. (Link)

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