Human sCD23 Platinum ELISA

Description: The human sCD23 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human sCD23. The human sCD23 ELISA is for research use only. Not for diagnostic or therapeutic procedures.

CD23 is described as a 45 kDa protein found on the surface of IgM bearing B cells, eosinophils, macrophages and some T and NK cells. It is also found on EBV-transformed B cells. Additionally, a released form has been described. When first released the CD23 molecule is 35 kDa; however, this form is quickly cleaved to obtain the more stable, soluble form which is 25 kDa in size.

Citations: ALEXEYEV,O.A.; LINDERHOLM,M.; ELGH,F.; WADELL,G.; JUTO,P.; TARNVIK,A.. Increased plasma levels of soluble CD23 in haemorrhagic fever with renal syndrome; relation to virus-specific IgE. Clinical and Experimental Immunology 1997;109:351-355. (Link)

Sluyter,Ronald; Wiley,James S.. Extracellular adenosine 5'-triphosphate induces a loss of CD23 from human dendritic cells via activation of P2X7 receptors. International Immunology 2002;14:1415-1421. (Link)

Birmann,Brenda M.; Mueller,Nancy; Okayama,Akihiko; Hsieh,Chung Cheng; Tachibana,Nobuyoshi; Tsubouchi,Hirohito; Lennette,Evelyne T.; Harn,Donald; Stuver,Sherri. Serologic Assessment of Type 1 and Type 2 Immunity in Healthy Japanese Adults. Cancer Epidemiology Biomarkers & Prevention 2004;13:1385-1391. (Link)

Puccetti,A.; Bason,C.; Simeoni,S.; Millo,E.; Tinazzi,E.; Beri,R.; Peterlana,D.; Zanoni,G.; Senna,G.; Corrocher,R.; Lunardi,C.. In chronic idiopathic urticaria autoantibodies against FceRII/CD23 induce histamine release via eosinophil activation. Clinical & Experimental Allergy 2005;35:1599-1607. (Link)

References: Kikutani,H.; Inui,S.; Sato,R.; Barsumian,E.L.; Owaki,H.; Yamasaki,K.; Kaisho,T.; Uchibayashi,N.; Hardy,R.R.; Hirano,T.; .. Molecular structure of human lymphocyte receptor for immunoglobulin E. Cell 1986;47:657-665. (Link)

Small,T.N.; Keever,C.A.; Weiner-Fedus,S.; Heller,G.; O'Reilly,R.J.; Flomenberg,N.. B-cell differentiation following autologous, conventional, or T-cell depleted bone marrow transplantation: a recapitulation of normal B-cell ontogeny. Blood 1990;76:1647-1656. (Link)

Dadmarz,R.; Cawley,J.C.. Heterogeneity of CLL: high CD23 antigen and alpha IFN receptor expression are features of favourable disease and of cell activation. Br.J.Haematol. 1988;68:279-282. (Link)

Cairns,J.; Flores-Romo,L.; Millsum,M.J.; Guy,G.R.; Gillis,S.; Ledbetter,J.A.; Gordon,J.. Soluble CD23 is released by B lymphocytes cycling in response to interleukin 4 and anti-Bp50 (CDw40). Eur.J.Immunol. 1988;18:349-353. (Link)