Recombinant Human sCD40 Ligand

Description: CD40L or CD154 is a membrane glycoprotein and differentiation antigen expressed on the surface of T-cells. The CD40 ligand stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines . CD40 ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also costimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma , TNF-alpha , and IL2 .

Biological Activity:
Determined by the stimulation of IL-12 induction by human peripheral blood mononuclear cells (PBMC). It also stimulates IL-8 induction by human PBMC using a concentration of 10-100 ng/mL.

Citations: Contin,Cecile; Pitard,Vincent; Delmas,Yahsou; Pelletier,Nadege; Defrance,Thierry; Moreau,Jean Francois; Merville,Pierre; Dechanet-Merville,Julie. Potential role of soluble CD40 in the humoral immune response impairment of uraemic patients. Immunology 2003;110:131-140. (Link)

Hoshino,Natsuki; Katayama,Naoyuki; Shibasaki,Tetsunori; Ohishi,Kohshi; Nishioka,Junji; Masuya,Masahiro; Miyahara,Yoshihiro; Hayashida,Masahiko; Shimomura,Daiki; Kato,Takuma; Nakatani,Kaname; Nishii,Kazuhiro; Kuribayashi,Kagemasa; Nobori,Tsutomu; Shiku,Hiroshi. A novel role for Notch ligand Delta-1 as a regulator of human Langerhans cell development from blood monocytes. Journal of Leukocyte Biology 2005;78:921-929. (Link)

Moschonas,Aristides; Kouraki,Maria; Knox,Pauline G.; Thymiakou,Efstathia; Kardassis,Dimitris; Eliopoulos,Aristides G.. CD40 Induces Antigen Transporter and Immunoproteasome Gene Expression in Carcinomas via the Coordinated Action of NF-{kappa}B and of NF-{kappa}B-Mediated De Novo Synthesis of IRF-1. Molecular and Cellular Biology 2008;28:6208-6222. (Link)

Blumberg,Neil; Gettings,Kelly F.; Turner,Chantal; Heal,Joanna M.; Phipps,Richard P.. An association of soluble CD40 ligand (CD154) with adverse reactions to platelet transfusions. Transfusion 2006;46:1813-1821. (Link)

Rckerl,Regina; Phipps,Richard P.; Schneider,Alexandra; Frampton,Mark; Cyrys,Josef; Oberd”rster,Gnther; Wichmann,H.Erich; Peters,Annette. Ultrafine particles and platelet activation in patients with coronary heart disease results from a prospective panel study. Particle and Fibre Toxicology 2007;4:1-1. (Link)

Kato,Kazunori; Santana-Sahagun,Ernesto; Rassenti,Laura Z.; Weisman,Michael H.; Tamura,Naoto; Kobayashi,Shigeto; Hashimoto,Hiroshi; Kipps,Thomas J.. The soluble CD40 ligand sCD154 in systemic lupus erythematosus. Journal of Clinical Investigation 1999;104:947-955. (Link)

Imai,Shinjiro; Tezuka,Hiroyuki; Furuhashi,Yuko; Muto,Riho; Fujita,Koichiro. A Factor of Inducing IgE from a Filarial Parasite Is an Agonist of Human CD40. Journal of Biological Chemistry 2001;276:46118-46124. (Link)

Davies,C.C.; Bem,D.; Young,L.S.; Eliopoulos,A.G.. NF-. Cellular Signalling 2005;17:729-738. (Link)

Matthies,K.M.G.; Newman,J.L.; Hodzic,A.; Wingett,D.G.. Differential regulation of soluble and membrane CD40L proteins in T cells. Cellular Immunology 2006;241:47-58. (Link)

Ruggiero,Giuseppina; Terrazzano,Giuseppe; Becchimanzi,Cristina; Sica,Michela; Andretta,Claudia; Masci,Anna Maria; Racioppi,Luigi; Rotoli,Bruno; Zappacosta,Serafino; Alfinito,Fiorella. GPI-defective monocytes from paroxysmal nocturnal hemoglobinuria patients show impaired in vitro dendritic cell differentiation. Journal of Leukocyte Biology 2004;76:634-640. (Link)

Nencioni,Alessio; Schwarzenberg,Karin; Brauer,Katharina M.; Schmidt,Susanne M.; Ballestrero,Alberto; Grunebach,Frank; Brossart,Peter. Proteasome inhibitor bortezomib modulates TLR4-induced dendritic cell activation. Blood 2006;108:551-558. (Link)

Nencioni,A.; Lauber,K.; Grunebach,F.; Brugger,W.; Denzlinger,C.; Wesselborg,S.; Brossart,P.. Cyclopentenone prostaglandins induce caspase activation and apoptosis in dendritic cells by a PPAR-@c-independent... Experimental Hematology 2002;30:1020-1028. (Link)

Appel,Silke; Bringmann,Anita; Grunebach,Frank; Weck,Markus M.; Bauer,Jurgen; Brossart,Peter. Epithelial-specific transcription factor ESE-3 is involved in the development of monocyte-derived DCs. Blood 2006;107:3265-3270. (Link)