Human sCD153 Platinum ELISA

Description: The human sCD153 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human sCD153. The human sCD153 ELISA is for research use only. Not for diagnostic or therapeutic procedures.

The human CD30 ligand, CD153, is a 40 kDa Type II transmembrane glycoprotein. It interacts with its receptor, CD30, as a homotrimer. Soluble trimeric CD153 binds to membrane-anchored CD30 with a relatively high affinity and is very effective in triggering cell death and TNF-alpha . CD153 is a member of the TNF superfamily which is primarily expressed by activated T cells, B cells and monocytes. Its function in programmed cell death has been proven, as well as its involvement in disorders like a variety of lymphoid malignancies like Hodgkin?s disease and anaplastic large cell lymphoma.

Citations: CARVALHO,RICARDO F.S.; ULFGREN,ANN KRISTIN; ENGSTROM,M.A.R.I.; KLINT,ERIK af; NILSSON,G.U.N.N.. CD153 in Rheumatoid Arthritis: Detection of a Soluble Form in Serum and Synovial Fluid, and Expression by Mast Cells in the Rheumatic Synovium. The Journal of Rheumatology 2009;36:501-507. (Link)

References: Shimozato,O.; Takeda,K.; Yagita,H.; Okumura,K.. Expression of CD30 ligand (CD153) on murine activated T cells. Biochem.Biophys.Res.Commun. 1999;256:519-526. (Link)

Armitage,R.J.. CD153. J.Biol.Regul.Homeost.Agents 2000;14:142-144. (Link)

Hargreaves,P.G.; Al-Shamkhani,A.. Soluble CD30 binds to CD153 with high affinity and blocks transmembrane signaling by CD30. Eur.J.Immunol. 2002;32:163-173. (Link)

Phillips,T.A.; Ni,J.; Hunt,J.S.. Cell-specific expression of B lymphocyte (APRIL, BLyS)- and Th2 (CD30L/CD153)-promoting tumor necrosis factor superfamily ligands in human placentas. J.Leukoc.Biol. 2003;74:81-87. (Link)

Goldie-Cregan,L.C.; Croager,E.J.; Abraham,L.J.. Characterization of the murine CD30 ligand (CD153) gene: gene structure and expression. Tissue Antigens 2002;60:139-146. (Link)

Cerutti,A.; Schaffer,A.; Goodwin,R.G.; Shah,S.; Zan,H.; Ely,S.; Casali,P.. Engagement of CD153 (CD30 ligand) by CD30+ T cells inhibits class switch DNA recombination and antibody production in human IgD+ IgM+ B cells. J.Immunol. 2000;165:786-794. (Link)