Human sCD137 (s4-1BB) Platinum ELISA

Description: The human sCD137 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human sCD137. The human sCD137 ELISA is for research use only. Not for diagnostic or therapeutic procedures.

CD137 (ILA/4-1BB) is a member of the tumor necrosis factor receptor family, expressed on activated T lymphocytes. The expression of CD137 is strictly activation dependent in primary cells. Co-stimulation through CD137 enhances T lymphocyte activation and may enable rejection of tumors in vivo. The gene for human CD137 resides on chromosome 1q36, in a cluster of related genes, and this chromosomal region is associated with mutations in several malignancies.

Soluble forms of members of the TNF receptor family have been demonstrated for the various members. The soluble isoforms of CD137, sCD137, are generated by differential splicing and can be detected at enhanced concentrations in sera of patients suffering from various diseases.

References: Sharief,M.K.. Heightened intrathecal release of soluble CD137 in patients with multiple sclerosis. Eur.J.Neurol. 2002;9:49-54. (Link)

Schwarz,H.; Tuckwell,J.; Lotz,M.. A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family. Gene 1993;134:295-298. (Link)

Lotz,M.; Setareh,M.; von,Kempis J.; Schwarz,H.. The nerve growth factor/tumor necrosis factor receptor family. J.Leukoc.Biol. 1996;60:1-7. (Link)

Kwon,B.S.; Weissman,S.M.. cDNA sequences of two inducible T-cell genes. Proc.Natl.Acad.Sci.U S A 1989;86:1963-1967. (Link)

Sica,G.; Chen,L.. Biochemical and immunological characteristics of 4-1BB (CD137) receptor and ligand and potential applications in cancer therapy 112. Arch.Immunol.Ther.Exp.(Warsz.) 1999;47:275-279. (Link)

Michel,J.; Langstein,J.; Hofstadter,F.; Schwarz,H.. A soluble form of CD137 (ILA/4-1BB), a member of the TNF receptor family, is released by activated lymphocytes and is detectable in sera of patients with rheumatoid arthritis. Eur.J.Immunol. 1998;28:290-295. (Link)

Simon,H.U.. Evidence for a pro-apoptotic function of CD137 in granulocytes. Swiss.Med.Wkly. 2001;131:455-458. (Link)

Smith,C.A.; Farrah,T.; Goodwin,R.G.. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. Cell 1994;76:959-962. (Link)

Michel,J.; Schwarz,H.. Expression of soluble CD137 correlates with activation-induced cell death of lymphocytes. Cytokine 2000;12:742-746. (Link)

Gruss,H.J.; Dower,S.K.. Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas. Blood 1995;85:3378-3404. (Link)