Human sCD134 (OX40) Platinum ELISA

Description: The human sCD134/OX40 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human sCD134/OX40. The human sCD134/OX40 ELISA is for research use only. Not for diagnostic or therapeutic procedures.

OX40 (CD134) is a member of the tumor necrosis (TNF) receptor superfamily and known to be an important costimulatory molecule expressed on activated T-cells. Interaction of OX40 with its ligand, OX40L, is thought to be important in T cell activation through T cell/antigen-presenting cell (APC) interaction. Ligation of OX40 induces clonal expansion and survival of CD4 cells during primary responses, and results in the accumulation of greater numbers of memory cells with time.

A soluble isoform of OX40 has been described. Measurement of this molecule may have diagnostic value in polymyositis and granulomatous myopathy, in T cell lymphoma and lymphomatoid papulosis, in proliferative lupus nephritis, in rheumatoid arthritis, in HIV infection, in viral infections of the lung, in the regulation of graft-versus-host disease, in myocarditis and dilated cardiomyopathy. The crucial role of OX40 in

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Gramaglia,I.; Jember,A.; Pippig,S.D.; Weinberg,A.D.; Killeen,N.; Croft,M.. The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion. J Immunol. 2000;165:3043-3050. (Link)

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Kunitomi,A.; Hori,T.; Maeda,M.; Uchiyama,T.. OX40 signaling renders adult T-cell leukemia cells resistant to Fas-induced apoptosis. Int.J Hematol. 2002;76:260-266. (Link)

Kotani,A.; Ishikawa,T.; Matsumura,Y.; Ichinohe,T.; Ohno,H.; Hori,T.; Uchiyama,T.. Correlation of peripheral blood OX40+(CD134+) T cells with chronic graft-versus-host disease in patients who underwent allogeneic hematopoietic stem cell transplantation. Blood 2001;98:3162-3164. (Link)

Bansal-Pakala,P.; Jember,A.G.; Croft,M.. Signaling through OX40 (CD134) breaks peripheral T-cell tolerance. Nat.Med 2001;7:907-912. (Link)

Ndhlovu,L.C.; Ishii,N.; Murata,K.; Sato,T.; Sugamura,K.. Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis. J Immunol. 2001;167:2991-2999. (Link)

Hoshino,A.; Tanaka,Y.; Akiba,H.; Asakura,Y.; Mita,Y.; Sakurai,T.; Takaoka,A.; Nakaike,S.; Ishii,N.; Sugamura,K.; Yagita,H.; Okumura,K.. Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma. Eur J Immunol. 2003;33:861-869. (Link)

Blazar,B.R.; Sharpe,A.H.; Chen,A.I.; Panoskaltsis-Mortari,A.; Lees,C.; Akiba,H.; Yagita,H.; Killeen,N.; Taylor,P.A.. Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients. Blood 2003;101:3741-3748. (Link)

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Rogers,P.R.; Song,J.; Gramaglia,I.; Killeen,N.; Croft,M.. OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity 2001;15:445-455. (Link)

Roos,A.; Schilder-Tol,E.J.; Weening,J.J.; Aten,J.. Strong expression of CD134 (OX40), a member of the TNF receptor family, in a T helper 2-type cytokine environment. J Leukoc.Biol 1998;64:503-510. (Link)

Sato,T.; Ishii,N.; Murata,K.; Kikuchi,K.; Nakagawa,S.; Ndhlovu,L.C.; Sugamura,K.. Consequences of OX40-OX40 ligand interactions in langerhans cell function: enhanced contact hypersensitivity responses in OX40L-transgenic mice. Eur J Immunol. 2002;32:3326-3335. (Link)

Ishii,N.; Ndhlovu,L.C.; Murata,K.; Sato,T.; Kamanaka,M.; Sugamura,K.. OX40 (CD134) and OX40 ligand interaction plays an adjuvant role during in vivo Th2 responses. Eur J Immunol. 2003;33:2372-2381. (Link)

Gniadecki,R.; Rossen,K.. Expression of T-cell activation marker CD134 (OX40) in lymphomatoid papulosis. Br.J Dermatol. 2003;148:885-891. (Link)

Seko,Y.; Ishiyama,S.; Nishikawa,T.; Kasajima,T.; Hiroe,M.; Suzuki,S.; Ishiwata,S.; Kawai,S.; Tanaka,Y.; Azuma,M.; Kobata,T.; Yagita,H.; Okumura,K.; Nagai,R.. Expression of tumor necrosis factor ligand superfamily costimulatory molecules CD27L, CD30L, OX40L and 4-1BBL in the heart of patients with acute myocarditis and dilated cardiomyopathy. Cardiovasc.Pathol. 2002;11:166-170. (Link)

Giacomelli,R.; Passacantando,A.; Perricone,R.; Parzanese,I.; Rascente,M.; Minisola,G.; Tonietti,G.. T lymphocytes in the synovial fluid of patients with active rheumatoid arthritis display CD134-OX40 surface antigen. Clin.Exp.Rheumatol 2001;19:317-320. (Link)

Aten,J.; Roos,A.; Claessen,N.; Schilder-Tol,E.J.; Ten Berge,I.J.; Weening,J.J.. Strong and selective glomerular localization of CD134 ligand and TNF receptor-1 in proliferative lupus nephritis. J Am Soc.Nephrol. 2000;11:1426-1438. (Link)

Taraban,V.Y.; Rowley,T.F.; O'Brien,L.; Chan,H.T.; Haswell,L.E.; Green,M.H.; Tutt,A.L.; Glennie,M.J.; Al-Shamkhani,A.. Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses. Eur J Immunol. 2002;32:3617-3627. (Link)

Takahashi,Y.; Tanaka,Y.; Yamashita,A.; Koyanagi,Y.; Nakamura,M.; Yamamoto,N.. OX40 stimulation by gp34/OX40 ligand enhances productive human immunodeficiency virus type 1 infection. J Virol. 2001;75:6748-6757. (Link)

Yoshioka,T.; Nakajima,A.; Akiba,H.; Ishiwata,T.; Asano,G.; Yoshino,S.; Yagita,H.; Okumura,K.. Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis. Eur J Immunol. 2000;30:2815-2823. (Link)

Murata,K.; Nose,M.; Ndhlovu,L.C.; Sato,T.; Sugamura,K.; Ishii,N.. Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases. J Immunol. 2002;169:4628-4636. (Link)