Anti-Human SAP (SLAM-Associated Protein) Purified

Description: This 10C4.2 monoclonal antibody reacts with human SLAM-associated protein (SAP). Upon SLAM receptor ligation, this 16-kDa SH2 domain-containing adaptor protein recruits Fyn tyrosine kinase, which phosphorylates the receptor to activate downstream signaling events. SAP is expressed in T, NK, and NKT cells, as well as eosinophils and platelets. This protein has also been detected in B cells and tumor cell lines such as Jurkat and Raji. Studies demonstrate that SAP expression in T follicular helper cells is required for germinal center formation. Moreover, this protein is involved in NKT cell development, Th1/Th2 differentiation, and controlling NK cytotoxicity. The role of SAP in B cells, however, is currently under investigation. Finally, deletion of the gene encoding SAP, SH2D1A, results in X-linked lymphoproliferative disease in humans.

References: Yusuf I, Kageyama R, Monticelli L, Johnston RJ, Ditoro D, Hansen K, Barnett B, Crotty S. Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150). J Immunol. 2010 Jul 1;185(1):190-202.

Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C. Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP. Blood. 2001 Jun 15;97(12):3867-74. (10C4.2, WB, ICC, Pubmed)

Sayós J, Nguyen KB, Wu C, Stepp SE, Howie D, Schatzle JD, Kumar V, Biron CA, Terhorst C. Potential pathways for regulation of NK and T cell responses: differential X-linked lymphoproliferative syndrome gene product SAP interactions with SLAM and 2B4. Int Immunol. 2000 Dec;12(12):1749-57. (10C4.2, WB, ICC, Pubmed)

Sayos J, Wu C, Morra M, Wang N, Zhang X, Allen D, van Schaik S, Notarangelo L, Geha R, Roncarolo MG, Oettgen H, De Vries JE, Aversa G, Terhorst C. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature. 1998 Oct 1;395(6701):462-9.