Anti-Human ROR gamma Purified

Description: The 4F3-3G8-2B7 monoclonal antibody reacts with the DNA binding domain of human and mouse RORγ protein. RORγ is a member of the retinoic acid-related orphan receptor (ROR) family, which also includes RORalpha and RORbeta. ROR family proteins are ligand-dependent transcription factors that play roles in multiple physiological processes. RORγ is expressed in several tissues, including liver, lung, muscle, heart and kidney. Furthermore, it was discovered that alternative transcription results in the expression of an isoform, RORγt, that is expressed exclusively in cells of the lymphoid compartment, namely CD4+CD8+ thymoyctes, Th17 cells of the periphery and lymphoid tissue inducer (Lti) cells of lymphoid organs.

The RORγt isoform differs from ROR by three unique amino acids at the amino terminus. Therefore, the 4F3-3G8-2 antibody will react with both the RORγ and RORγt isoforms. In addition our data suggests that 4F3-3C8-2B7 has greater sensitivity to human RORγ than to mouse RORγ. For detection of mouse RORγ, please use cat. 14-6981.

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He YW, Deftos ML, Ojala EW, Bevan MJ. RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells. Immunity. 1998 Dec;9(6):797-806.

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