Anti-Human/Rat CX3CR1 Purified

Description: The rabbit polyclonal antibody reacts with recombinant and natural human and rat CX3CR1; the antibody was generated using E. coli-expressed human CX3CR1 amino terminal domain as an immunogen. CX3CR1, also termed neurotactini or fractalkine, is a membrane-bound CX3C chemokine. Human CX3CR1, also named V28, was first cloned from human genomic DNA libraries. A G-protein-coupled seven-transmembrane domain receptor, it was recently identified to serve as fractalkine receptor. Human CX3CR1 has been shown to mediate both the adhesive and migratory functions of fractalkine. Fractalkine and CX3CR1 represent new types of leukocyte trafficking regulators. Cross reactivity to CX3CR1 of other species has not been determined.

References: Bazan J.F. et al. 1997. A new class of membrane-bound chemokine with a CX3C motif. Nature 385:640-644

Harrison, J.K. et al. 1994. cDNA cloning of a G-protein-coupled receptor expressed in rat spinal cord and brain related to chemokine receptors. Neurosci Lett 169:85-89

Imai, T. et al. 1997. Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 91:521-530

Combadiere C. et al. 1998. Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV. J Biol Chem 273(37):23799-23804

Hung S, Pochampally RR, et al. 2007. Short-term exposure of multipotent stromal cells to low oxygen increases their expression of CX3CR1 and CXCR4 and their engraftment in vivo. PLoS ONE. 2(5):e416. (WB, PubMed)