Anti-Human PDX1 Alexa Fluor® 647 (To Be Discontinued. Refer to Cat. No. 50-6500)

Also known as: pancreatic and duodenal homeobox protein, insulin promoter factor 1

Clone: 2A12

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 51-6500

Cat. No.	Size
51-6500-80	25 ug
51-6500-82	100 ug
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Immunohistochemistry on formalin-fixed paraffin embedded human pancreas using 20 ug/mL of Mouse IgG1...View More

Description

Description: This 2A12 monoclonal antibody reacts with the transcriptional activator PDX1, also known as pancreatic and duodenal homeobox protein and insulin promoter factor. Early expression of PDX1 during development marks the endoderm from which the pancreas, stomach, and duodenum derive. In the mature pancreas, expression is found in insulin-expressing beta-cells. PDX1 functions as an important regulator of several key pancreatic proteins including insulin, somatostatin, glucokinase, islet amyloid factor, and glucose transporter type 2. Deficiency in PDX1 results in a dysregulation of the beta-cell compensation of insulin resistance, which can lead to late-onset type 2 diabetes mellitus (formerly NIDDM) and maturity onset diabetes of the young type 4 (MODY4).

Details

Host	Mouse
Isotype	IgG1
Reactivity	Human
Conjugate	Alexa Fluor 647
Laser	Red Laser
Emit	668 nm
Excite	633 - 647 nm
Concentration	0.2 mg/mL
Formulation	aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Legal	Alexa Fluor® and Pacific Blue® are registered trademarks of and licensed under patents assigned to Molecular Probes, Inc. for research use only. This product is subject to an agreement between Molecular Probes, Inc. and eBioscience, and the manufacture, use, sale or import of this product may be subject to one or more U.S. patents, pending applications and corresponding foreign equivalents, owned by Molecular Probes, Inc. (a wholly owned subsidiary of Invitrogen Corp). The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product for life science research or as an ASR. The buyer cannot use this product for manufacturing or for any other screening (specifically including use in combination with microarrays or High Content Screening) or testing purpose, other than as an ASR. For information on purchasing a license to this product for purposes other than life science research or use as an ASR, contact Molecular Probes, Inc.
Reported Applications	Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections, Immunocytochemistry

Documentation

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
50-6500	Anti-Human PDX1 eFluor® 660	633 - 647 nm	668 nm	ICC, IHC	RUO
14-6500	Anti-Human PDX1 Purified			ICC, IHC	RUO

Related Products

Cat. No.	Name	Excite	Emit	Application	Reg.
00-4958	Fluoromount-G™			ICC, IHC	GPR
51-4714	Mouse IgG1 K Isotype Control Alexa Fluor® 647 (Discontined. Refer to Cat. No. 50-4714)	633 - 647 nm	668 nm	FC, ICC, IHC	RUO
00-4955	IHC Antigen Retrieval Solution – Low pH (10X)			IHC	GPR

References

References: Li SW, Koya V, Li Y, Donelan W, Lin P, Reeves WH, Yang LJ. Pancreatic duodenal homeobox 1 protein is a novel beta-cell-specific autoantigen for type I diabetes. Lab Invest. 2010 Jan;90(1):31-9.

Sachdeva MM, Claiborn KC, Khoo C, Yang J, Groff DN, Mirmira RG, Stoffers DA. Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress. Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19090-5.

Fujimoto K, Hanson PT, Tran H, Ford EL, Han Z, Johnson JD, Schmidt RE, Green KG, Wice BM, Polonsky KS. Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation. J Biol Chem. 2009 Oct 2;284(40):27664-73.

View More Products

Antigens	Area of Biology	Formats
Pdx1	Metabolism Transcription Factors	Alexa Fluor 647