Human PDGF-BB Recombinant Protein

Description: PDGF-BB is a member of the platelet-derived growth factor family, a group of proteins that are released by platelets upon activation. The PDGF proteins are dimers of two of four peptide chains designated A, B, C, and D. PDGF-BB is formed by two B-chains, while PDGF-AB is one B chain and one A-chain forming the only heterodimer in the family. PDGF-BB is unique among the family in that it can bind to and activate all three forms of the PDGF receptor. It induces the proliferation, migration, and survival of fibroblasts, endothelial cells, epithelial cells, and smooth muscle cells. PDGF-BB is important for angiogenesis and smooth muscle formation during embryonic development, and plays a role in wound healing and regeneration in adults. High levels of PDGF-BB are often detected in malignant tumors, and it is believed to facilitate tumor metastasis and vascularization.

References: Nissen LJ, Cao R, Hedlund EM, Wang Z, Zhao X, Wetterskog D, Funa K, Brakenhielm E, Cao Y. Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis. J Clin Invest. 2007 Oct;117(10):2766-77.

Cao Y. Direct role of PDGF-BB in lymphangiogenesis and lymphatic metastasis. Cell Cycle. 2005 Feb;4(2):228-30.

Kamimura M, Bea F, Akizawa T, Katus HA, Kreuzer J, Viedt C. Platelet-derived growth factor induces tissue factor expression in vascular smooth muscle cells via activation of Egr-1. Hypertension. 2004 Dec;44(6):944-51.