Description: The human PDGF-BB ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human PDGF-BB. The human PDGF-BB ELISA is for research use only. Not for diagnostic or therapeutic procedures.
Platelet-derived growth factors (PDGFs) are a family of dimeric disulfide-bound growth factors that bind to two structurally related tyrosine kinase receptors, the PDGF-alpha and PDGF-beta receptors (170 kDa and 180 kDa, respectively). PDGF-AA, PDGF-BB, and PDGF-AB, PDGF-CC and PDGF-DD are PDGFs discovered so far.
The major producers of PDGF are megakaryocytes. alpha-granules of platelets are a major storage site for PDGF, from which it is released after cell activation. PDGF can furthermore be produced by a number of various cell types. PDGF is a potent mitogen and chemotactic factor for mesenchymal cells such as fibroblasts, vascular smooth muscle cells, glomerular mesangial cells, and brain grail cells.
PDGF plays an important role in embryonal development. In kidneys, blood vessels, lungs, connective tissue, and the central nervous system, connective tissue-like cell types depend on PDGF. PDGF affects wound healing; the growth factor increases the rate of repair.