Human p53 Platinum ELISA

Description: The human p53 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human p53. The human p53 ELISA is for research use only. Not for diagnostic or therapeutic procedures.

p53 is a tumor suppressor that is regulated by transcriptional, post-transcriptional, and post-translational mechanisms in response to stress. Studies demonstrate that p53 is critical for the prevention of tumorigenesis and may potentially be involved in at least half of all known cancers. p53 functions as a transcription factor to regulate genes involved in apoptosis, cell cycle, senescence, metabolism, angiogenesis, immunity, differentiation, and migration. Moreover, p53 is phosphorylated at multiple sites, including Ser15, following DNA damage.

Citations: Su,Changqing; Cao,Hui; Tan,Shuping; Huang,Yao; Jia,Xiaoyuan; Jiang,Lixin; Wang,Kai; Chen,Ying; Long,Ju; Liu,Xinyuan; Wu,Mengchao; Wu,Xiaobing; Qian,Qijun. Toxicology Profiles of a Novel p53-Armed Replication-Competent Oncolytic Adenovirus in Rodents, Felids, and Nonhuman Primates. Toxicological Sciences 2008;106:242-250. (Link)

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