Anti-Human/Non-Human Primate CD18 PE

Description: The 6.7 monoclonal antibody reacts with human and non-human primate (rhesus or cynomologus) CD18, which is also known as β2 integrin. CD18 is a 90-95 kDa type I transmembrane protein that heterodimerizes with the a chain of CD11a, CD11b and CD11c. The CD18/CD11a complex is also known as lymphocyte function-associated antigen-1 (LFA-1) and plays an important role in cellular adhesion and inflammatory reactions. CD18 is expressed broadly by human lymphocytes and monocytes. Peripheral blood granulocytes also express CD18, but at lower levels.

The 6.7 monoclonal antibody has been reported to induce the proliferation of resting T cells cultured with monocytes.

References: Caldas C, Coelho V, Kalil J, Moro AM, Maranhão AQ, Brígido MM. ization of the anti-CD18 antibody 6.7: an unexpected effect of a framework residue in binding to antigen. Mol Immunol. 2003 May;39(15):941-52. (6.7, FC)

David V, Leca G, Corvaia N, Le Deist F, Boumsell L, Bensussan A. Proliferation of resting lymphocytes is induced by triggering T cells through an epitope common to the three CD18/CD11 leukocyte adhesion molecules. Cell Immunol. 1991 Sep;136(2):519-24. (6.7, FG)

Reinherz, E. L., B. F. Haynes, L. M. Nadler, I. D. Bernstein eds. 1986. Leukocyte Typing II, Springer-Verlag Inc., New York.