Anti-Non-Human Primate/Rat alpha beta TCR Functional Grade Purified

Description: This R73 monoclonal antibody reacts with the rat and non-human primate T cell receptor α/β chain. αβ TCR is expressed by a majority of thymocytes and peripheral T cells, and intestinal intraepithelial lymphocytes. Cross-linking of the TCR complex with R73 induces the differentiation and activation of T cells.

The R73 antibody crossreacts with macaques and rhesus monkey.

References: Yoshino N, Ami Y, Terao K, Tashiro F, Honda M. Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies. Exp Anim. 2000 Apr;49(2):97-110.

Brenan, M., D.J.G. Rees. Sequence analysis of rat integrin aE1 and aE2 subunits: tissue expression reveals phenotypic similarities between intraepithelial lymphocytes and dendritic cells in lymph." Eur J Immunol. 1997 27: 3070-79.

Pieters, R.H.H., P. Punt, M. Bol, J.M. van Dijken, W. Seinen, A.H. Penninks. The thymus atrophy inducing organotin compound DBTC stimulates TCRab–CD3 signaling in immature rat thymocytes. Biochem Biophys Res Commun. 1995 214: 552-58.

Fangman, J., R. Schwinzer, K. Wonigeit. Unusual phenotype of intestinal intraepithelial lymphocytes in the rat: predominance of T cell receptor a/b+/CD2-cells and high expression of the RT6 alloantigen." Eur J Immunol. 1991 21:753-60.

Hunig, T., H.J. Wallny, J.K. Hartley, A. Lawetzky, G. Tiefenthaler. A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. Differential reactivity with subsets of immature and mature T lymphocytes." J Exp Med. 1989 169: 73-86.