Neural/Glial Antigen 2 (NG2) PE

Description: The 9.2.27 monoclonal antibody reacts with human neural/glial antigen 2, which is also known as melanoma chondroitin sulfate proteoglycan (MCSP). This antigen is composed of a 250 kDa N-linked glycoprotein and a >450 kDa proteoglycan. NG2 is expressed on glioma cells, as well as on developing and adult oligodendrocyte precursor cells. NG2 functions as a coreceptor for alpha4beta1 integrin.

References: Pluschke G, Vanek M, Evans A, Dittmar T, Schmid P, Itin P, Filardo EJ, Reisfeld RA. Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9710-5

Bumol TF, Reisfeld RA. Unique glycoprotein-proteoglycan complex defined by monoclonal antibody on human melanoma cells.Proc Natl Acad Sci U S A. 1982 Feb;79(4):1245-9.