Anti-Human Nestin Purified

Description: The monoclonal antibody 10C2 recognizes human nestin (residues 1464-1614). Nestin is a 220-240 kDa Class VI intermediate filament protein that is expressed in stem cells of the developing nervous system, specifically the neuroepithelium and angiogenic cells, and progenitors of pancreatic islet and mesenchymal cells. Additionally, expression has been identified in a variety of tumors such as glioblastomas and pancreatic tumors. Nestin containing filaments upon differentitation are replaced by cell type specific intermediate filament proteins, such as GFAP. No co-reactivity to rodent nestins has been observed using 10C2 antibody.

References: Messam CA, Ding S, Haydon PG. Functional differentiation of human brain progenitor cells. Neuron Glia Biol. 2006 Aug;2(3):187-98.

Linning KD, Tai MH, Madhukar BV, Chang CC, Reed DN Jr, Ferber S, Trosko JE, Olson LK. Redox-mediated enrichment of self-renewing adult human pancreatic cells that possess endocrine differentiation potential. Pancreas. 2004 Oct;29(3):e64-76.

Messam CA, Hou J, Major EO. Coexpression of nestin in neural and glial cells in the developing human CNS defined by a human-specific anti-nestin antibody. Exp Neurol. 2000 Feb;161(2):585-96.