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Anti-Human Nestin Alexa Fluor® 488

Also known as: NES, type VI intermediate filament (IF) protein

Clone: 10C2

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 53-9843

Cat. No. Size
53-9843-82 100 ug
53-9843-80 25 ug
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Data for Anti-Human Nestin Alexa Fluor® 488.

Immunocytochemistry of fixed and permeabilized SK-N-SH cells using 10 ug/ml of Mouse IgG1 kappa...View More

  • Data for Anti-Human Nestin Alexa Fluor® 488.
Description

Description: The monoclonal antibody 10C2 recognizes human nestin (residues 1464-1614). Nestin is a 220-240 kDa Class VI intermediate filament protein that is expressed in stem cells of the developing nervous system, specifically the neuroepithelium and angiogenic cells, and progenitors of pancreatic islet and mesenchymal cells. Additionally, expression has been identified in a variety of tumors such as glioblastomas and pancreatic tumors. Nestin containing filaments upon differentiation are replaced by cell type specific intermediate filament proteins, such as GFAP. No co-reactivity to rodent nestins has been observed using 10C2 antibody.

Details
Host Mouse
Isotype IgG1
Reactivity Human
Conjugate Alexa Fluor 488
Laser Blue Laser
Emit 519 nm
Excite 488 nm
Legal Alexa Fluor® and Pacific Blue® are registered trademarks of and licensed under patents assigned to Molecular Probes, Inc. for research use only. This product is subject to an agreement between Molecular Probes, Inc. and eBioscience, and the manufacture, use, sale or import of this product may be subject to one or more U.S. patents, pending applications and corresponding foreign equivalents, owned by Molecular Probes, Inc. (a wholly owned subsidiary of Invitrogen Corp). The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product for life science research or as an ASR. The buyer cannot use this product for manufacturing or for any other screening (specifically including use in combination with microarrays or High Content Screening) or testing purpose, other than as an ASR. For information on purchasing a license to this product for purposes other than life science research or use as an ASR, contact Molecular Probes, Inc.
Reported Applications Immunohistochemical Staining, Immunocytochemistry
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
14-9843 Anti-Human Nestin Purified IHC, WB RUO
Related Products
Cat. No. Name Excite Emit Application Reg.
53-4714 Mouse IgG1 K Isotype Control Alexa Fluor® 488 488 nm 519 nm FC, ICC, IHC RUO
References

References: Messam CA, Ding S, Haydon PG. Functional differentiation of human brain progenitor cells. Neuron Glia Biol. 2006 Aug;2(3):187-98.

Linning KD, Tai MH, Madhukar BV, Chang CC, Reed DN Jr, Ferber S, Trosko JE, Olson LK. Redox-mediated enrichment of self-renewing adult human pancreatic cells that possess endocrine differentiation potential. Pancreas. 2004 Oct;29(3):e64-76.

Messam CA, Hou J, Major EO. Coexpression of nestin in neural and glial cells in the developing human CNS defined by a human-specific anti-nestin antibody. Exp Neurol. 2000 Feb;161(2):585-96.

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