Anti-TACE (ADAM17) Purified

Description: The polyclonal antibody reacts with human, mouse, and rat TACE; the antibody was raised against residues 807-823 of human ADAM17, also known as TACE (TNF-α Converting Enzyme), and recognizes human, mouse and rat ADAM17. ADAM17/TACE is a member of the ADAM (A Disintegrin And Metalloprotease) family of membrane-anchored glycoproteins comprised of several distinct protein modules, including a pro- and metalloprotease domain, disintegrin domain, cysteine-rich region and an EGF repeat. ADAM17 converts TNF-α from its membrane-bound precursor (26 kDa) to generate the secreted mature form (17 kDa). ADAM17 also processes other molecules such as TNF receptor, TGF-α, and CD62L (L-Selectin). ADAM17 is expressed by a variety of human and mouse tissues.

References:
Vincent, B., E. Paitel, et al. 2001. The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein. J Biol Chem 276:37743-6
Hurtado, O., A. Cardenas, et al. 2001. Up-regulation of TNF-alpha convertase (TACE/ADAM17) after oxygen-glucose deprivation in rat forebrain slices. Neuropharmacology 40:1094-102
Nelson, K. K., J. Schlondorff, et al. 1999. Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta. Biochem J 343: 673-80
Mizui, Y., K. Yamazaki, et al. 1999. cDNA cloning of mouse tumor necrosis factor-alpha converting enzyme (TACE) and partial analysis of its promoter. Gene 233: 67-74