Anti-CX3CR1 Purified

Description: The polyclonal rabbit antibody reacts with human, mouse, and rat Fractalkine; the antibody was raised against a peptide corresponding to amino acids 2 to 21 of human Fractalkine (CX3CR1), this sequence of human CX3CR1 differs from those of mouse and rat by four amino acids. CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, murine, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1 and RBS11, respectively. The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1. Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine. CX3CR1 mediates leukocyte migration and adhesion. CX3CR1 is expressed in a variety of human tissues and cell lines.

References:
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Combadiere C, Gao J, Tiffany HL, Murphy PM. 1998. Gene cloning, RNA distribution, and functional expression of mCX3CR1, a mouse chemotactic receptor for the CX3C chemokine fractalkine. Biochem Biophys Res Commun. 253:728-32
Harrison JK, Barber CM, Lynch KR. 1994. cDNA cloning of a G-protein-coupled receptor expressed in rat spinal cord and brain related to chemokine receptors. Neurosci Lett. 169:85-9
Imai T, Hieshima K, Haskell C, Baba M, Nagira M, Nishimura M, Kakizaki M, Takagi S, Nomiyama H, Schall TJ, Yoshie O. 1997. Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell. 91:521-30
Combadiere C, Salzwedel K, Smith ED, Tiffany HL, Berger EA, Murphy PM. 1998. Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1. J Biol Chem. 273:23799-804