Anti-CX3CL1 (Fractalkine) Purified

Description: The rabbit polyclonal antibody reacts with recombinant and natural mouse, rat, and human fractalkine (CX3CL1); the antibody was generated using E. coli-expressed chemotactic domain of human CX3CL1 as an immunogen. CX3CL1, also known as neurotactin or fractalkine, is a membrane-bound CX3C chemokine. The mature protein is part of a 397-amino acid precursor and consists of a chemokine domain of 76 amino acids, a mucin stalk of 241 amino acids, a putative transmembrane domain of 18 amino acids, and an intracellular tail of 37 amino acids. Within the chemokine domain, the first two cysteine residues are separated by 3 amino acids (CX3C). CX3CL1 message is found in high abundance in the brain, kidney, lung and heart tissues. CX3CL1 is chemotactic for monocytes and other leukocytes including NK cells and may play a role in brain inflammation.

References: Bazan J.F. et al. 1997. A new class of membrane-bound chemokine with a CX3C motif. Nature 385:640-644

Pan, Y. et al. 1997. Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. Nature 387:611-617

Imai, T. et al. 1997. Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 91:521-530.

Sawai H, Park YW, et al. 2005. T cell costimulation by fractalkine-expressing synoviocytes in rheumatoid arthritis. Arthritis Rheum. 52(5):1392-401. (IHC frozen in human tissue, PubMed)