Anti-Human/Mouse Integrin beta 7 Biotin

Description: The FIB504 monoclonal antibody reacts with human and mouse integrin β7. Integrin β7 is a 130 kD glycoprotein which associates with integrin α4 (CD49d) to form the α4β7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with αE (CD103) to form the αEβ7 integrin HML-1, expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Main ligands for integrin α4β7 include VCAM-1 (CD106), MAdCAM-1 and fibronectin, while the main ligand of integrin αEβ7 is E-cadherin (CD324). Integrin β7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response. The FIB504 antibody has been reported to have blocking activity.

References: Rodriguez MW, Paquet AC, Yang YH, Erle DJ. Differential gene expression by integrin beta7+ and beta7- memory T helper cells. BMC Immunol. 2004 Jul 5;5:13. (FIB504, FC, PubMed)

Meerschaert J, Vrtis RF, Shikama Y, Sedgwick JB, Busse WW, Mosher DF. Engagement of alpha4beta7 integrins by monoclonal antibodies or ligands enhances survival of human eosinophils in vitro. J Immunol. 1999 Dec 1;163(11):6217-27. (FIB504, FA, PubMed)

Andrew DP, Berlin C, Honda S, Yoshino T, Hamann A, Holzmann B, Kilshaw PJ, Butcher EC. Distinct but overlapping epitopes are involved in alpha4beta7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation. J Immunol. 1994 Nov 1;153(9):3847-61. (FIB504, FA, PubMed)