Anti-Human/Mouse FOXJ1 Purified

Description: This 2A5 monoclonal antibody reacts with Foxj1, a 50-kDa member of the Forkhead-box (FOX) family of winged-helix transcription factors. Expression of Foxj1 is high in ciliated epithelial cells and low in naïve T and B cells, where cellular activation results in downregulation of the factor. Foxj1 modulates germinal center formation and Th1 activation by repressing NFκB through IκBβ induction. As such, this transcription factor has been suggested to antagonize autoimmune reactions such as systemic lupus erythematosus and rheumatoid arthritis. In addition, Foxj1 has been linked to the formation of motile cilia in epithelial cells.

References: Yu X, Ng CP, Habacher H, Roy S. Foxj1 transcription factors are master regulators of the motile ciliogenic program. Nat Genet. 2008 Dec;40(12):1445-53.

Pan J, You Y, Huang T, Brody SL. RhoA-mediated apical actin enrichment is required for ciliogenesis and promoted by Foxj1. J. Cell Sci. 2007 Jun 1;120(Pt 11):1868-76. (2A5, WB, IF, Pubmed)

Lin L, Brody SL, Peng SL. Restraint of B cell activation by FOXJ1-mediated antagonism of NFkappaB and IL-6. J. Immunol. 2005, 175: 951-958.

Lin L, Spoor MS, Gerth AJ, Brody SL, Peng SL. Modulation of Th1 activation and inflammation by the NFkappaB repressor FOXJ1. Science 2004, 303: 1017.