Anti-Human/Mouse CD62P (P-Selectin) APC

Description: The Psel.KO2.3 monoclonal antibody reacts with mouse CD62P (also known as P-selectin and GMP-140), a 140-kDa cell adhesion molecule that can be induced on endothelial cells and platelets. During inflammation, this selectin mediates adhesion of monocytes and neutrophils to activated platelets, as well as leukocyte rolling on endothelial cells. The major ligand for CD62P on neutrophils is P-selectin glycoprotein ligand-1 (PSGL-1). This monoclonal antibody recognizes an epitope that is conserved across several species (e.g. mouse, human, and rat) and has not been reported to block cell adhesion.

References: Matsumoto, M., et al. CD43 plays both antiadhesive and proadhesive roles in neutrophil rolling in a context-dependent manner. J. Immunol. 2008, 181: 3628-35.

Massaguer, A., et al. Production and characterization of monoclonal antibodies against conserved epitopes of P-selectin (CD62P) Tissue antigens 2000, 56: 117-28. (Psel.KO2.3, FC, Pubmed)

Bullard, D.C., et al. Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. J. Exp. Med. 1996, 183: 2329-36.

Kansas, G.S. Selectins and their ligands: current concepts and controversies. Blood 1996, 88:3259-87.