Anti-Human/Non-Human Primate IFN gamma Purified

Also known as: Interferon-gamma

Clone: MD-1

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 14-7317

Cat. No. Size
14-7317-81 50 ug
14-7317-85 500 ug
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Data for Anti-Human/Non-Human Primate IFN gamma Purified.

Human PBMCs were activated with PMA/Ionomycin in Human IFN gamma ELISPOT assay. Control well is...View More

  • Data for Anti-Human/Non-Human Primate IFN gamma Purified.
Description

Description: The MD-1 antibody reacts with human, rhesus, cynomolgus and baboon interferon-gamma (IFN gamma), the signature Th1 cytokine, which is produced mainly by activated T cells, NK cells and B cells. IFN gamma is a dimeric protein. IFN gamma has antiviral and antiparasitic activities and also inhibits the proliferation of normal and transformed cells.

Details
Host Mouse
Isotype IgG1, kappa
Reactivity Human, Monkey
Conjugate Purified
Reported Applications Intracellular Staining Followed by Flow Cytometric Analysis, ELISA Capture Antibody, ELISPOT Capture Antibody, Immunohistochemical Staining of Frozen Tissue Sections, Cytokine Neutralization, Western Blotting
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
16-7317 Anti-Human/Non-Human Primate IFN gamma Functional Grade Purified ELISA RUO
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References

References: Gong G, Shao L, Wang Y, Chen CY, Huang D, Yao S, Zhan X, Sicard H, Wang R, Chen ZW. Phosphoantigen-activated V gamma 2V delta 2 T cells antagonize IL-2-induced CD4+CD25+Foxp3+ T regulatory cells in mycobacterial infection. Blood. 2009 Jan 22;113(4):837-45. (MD-1, cross to cynomolgus, NU, PubMed)

Jurado JO, Alvarez IB, Pasquinelli V, Martínez GJ, Quiroga MF, Abbate E, Musella RM, Chuluyan HE, García VE. Programmed death (PD)-1:PD-ligand 1/PD-ligand 2 pathway inhibits T cell effector functions during human tuberculosis. J Immunol. 2008 Jul 1;181(1):116-25. (MD-1, FA, PubMed)

van der Meide PH, Groenestein RJ, de Labie MC, Heeney J, Pala P, Slaoui M. Enumeration of lymphokine-secreting cells as a quantitative measure for cellular immune responses in rhesus macaques. J Med Primatol. 1995 Dec;24(4):271-81.

Wassenaar A, Reinhardus C, Thepen T, Abraham-Inpijn L, Kievits F. Cloning, characterization, and antigen specificity of T-lymphocyte subsets extracted from gingival tissue of chronic adult periodontitis patients. Infect Immun. 1995 Jun;63(6):2147-53. (MD-1, IHC frozen)

van Besouw NM, van der Meide PH, Bakker NP. The mitogen-induced generation of interferon-gamma producing cells in cultures of rhesus monkey peripheral blood mononuclear cells is age-dependent. J Med Primatol. 1994 Jan;23(1):42-8.

Yazdanbakhsh M, Sartono E, Kruize YC, Kurniawan A, van der Pouw-Kraan T, van der Meide PH, Selkirk ME, Partono F, Hintzen RQ, van Lier RA, et al. Elevated levels of T cell activation antigen CD27 and increased interleukin-4 production in human lymphatic filariasis. Eur J Immunol. 1993 Dec;23(12):3312-7.

Van der Meide PH, Dubbeld M, Schellekens H. Monoclonal antibodies to human immune interferon and their use in a sensitive solid-phase ELISA. J Immunol Methods. 1985 May 23;79(2):293-305.