anti-human MnSOD

Description: Recognizes human Mn SOD. Cross-reacts with rat and rabbit Mn SOD.

The antibody can be used to stain both indirectly or directly acetone-fixed cryostat sections or cell smears.
BMS122 is suitable for Western blot application. Under reducing conditions/SDS electrophoresis using BMS122 a 25 kDa band will be recognized (monomer of MnSOD protein).

Human MnSOD is a tetrameric enzyme with four identical subunits each harboring a Mn+3 atom. MnSOD catalyzes the dismutation of two molecules of superoxide anion into water and hydrogen peroxide.

Citations: Gallagher,Anna Rachel; Cedzich,Anna; Gretz,Norbert; Somlo,Stefan; Witzgall,Ralph. The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton. Proceedings of the National Academy of Sciences U.S.A. 2000;97:4017-4022. (Link)

Acquaviva,Fabio; De Biase,Irene; Nezi,Luigi; Ruggiero,Giuseppina; Tatangelo,Fabiana; Pisano,Carmela; Monticelli,Antonella; Garbi,Corrado; Acquaviva,Angela Maria; Cocozza,Sergio. Extra-mitochondrial localisation of frataxin and its association with IscU1 during enterocyte-like differentiation of the human colon adenocarcinoma cell line Caco-2. Journal of Cell Science 2005;118:3917-3924. (Link)