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Human MIG Instant ELISA

Also known as: CRG-10, Humig, SCYB9, CXCL9

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# BMS285INST*

Cat. No. Size
BMS285INST 128 tests
Please inquire about custom configurations or bulk packaging.

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Data for Human MIG Instant ELISA.

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  • Data for Human MIG Instant ELISA.
Description

Description: The human MIG Instant ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of of human MIG. The human MIG Instant ELISA is for research use only. Not for diagnostic or therapeutic procedures.

MIG (monokine induced by interferon gamma) belongs to the subfamily of the CXC chemokines. The main function of this soluble protein is the recruitment of leukocytes to sites of infection and inflammation.

MIG binds to a receptor which is selectively expressed in activated T lymphocytes and therefore is a critical mediator of T-lymphocyte migration in T-cell dependent immune responses. This displays antiviral activity. Like IP-10 it binds to chemokine receptor CXCR3 in Th1 immune reactions and exhibits inhibitory functions in neovascularization, is an inhibitor for hematopoietic progenitor cells and shows anti-tumor effects.

Furthermore there are indications that MIG plays an important role in mediating cell recruitment and activation necessary for inflammation and the repair of tissue damage e.g. in liver diseases.

Details
Reactivity Human
Sample Volume 50 uL
Suitable Sample Types cell culture supernatant, serum
Sensitivity 4.0 pg/mL
Standard Curve Range 31.3 - 2,000 pg/mL
Components Aluminium pouch(es) with a Microwell Plate coated with Monoclonal Antibody (murine ) to human MIG, Biotin-Conjugate (anti-human-MIG monoclonal antibody) Sample Diluent, and Streptavidin-HRP, lyophilized
Aluminium pouch(es) with a human MIG Standard curve (coloured)
Wash Buffer Concentrate 20x (phosphate-buffered saline with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Sample Diluent (Use when an external predilution of the samples is needed)
Stop Solution (1M Phosphoric acid)
Adhesive Plate Covers
Reported Applications ELISA
Documentation
TDS Link Download TDS
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References

References: Kaplan,A.P.. Chemokines, chemokine receptors and allergy. Int.Arch.Allergy Immunol. 2001;124:423-431. (Link)

Lalor,P.F.; Shields,P.; Grant,A.; Adams,D.H.. Recruitment of lymphocytes to the human liver. Immunol.Cell Biol. 2002;80:52-64. (Link)

Moser,B.; Loetscher,M.; Piali,L.; Loetscher,P.. Lymphocyte responses to chemokines. Int.Rev.Immunol. 1998;16:323-344. (Link)

Farber,J.M.. Mig and IP-10: CXC chemokines that target lymphocytes. J.Leukoc.Biol. 1997;61:246-257. (Link)

Ramshaw,I.A.; Ramsay,A.J.; Karupiah,G.; Rolph,M.S.; Mahalingam,S.; Ruby,J.C.. Cytokines and immunity to viral infections. Immunol.Rev. 1997;159:119-135. (Link)

Baggiolini,M.; Dewald,B.; Moser,B.. Human chemokines: an update. Annu.Rev.Immunol. 1997;15:675-705. (Link)

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