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Anti-Human MerTK Purified

Also known as: Mer, c-mer

Clone: A3KCAT

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 14-9053

Cat. No. Size
14-9053-80 25 ug
14-9053-82 100 ug
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Data for Anti-Human MerTK Purified.

Immunohistochemistry of formalin-fixed paraffin embedded human testes tissue using 0.5 ug/mL of...View More

  • Data for Anti-Human MerTK Purified.
Description

Description: This A3KCAT antibody recognizes human MerTK, known also as MER or c-mer, a 170-210 kDa member of the TAM family of tyrosine kinase receptors that also includes Axl and Tyro3. MerTK is expressed on a subset of anti-inflammatory macrophages and is involved in the removal of apoptotic cells. This process relies on two soluble ligands of MerTK, Protein S and Gas6, that coat the surface of cells undergoing apoptosis. Upon binding these ligands, MerTK undergoes autophosphorylation at multiple tyrosine residues that activate the PI3K and Akt pathways. This results in the phagocytosis of target cells and also the direct inhibition of TLR-induced production of pro-inflammatory cytokines by the phagocytes. MerTK may also function as a putative entry receptor for filoviruses. Deficiency of MerTK causes general autoimmunity, inflammation, and accumulation of apoptotic bodies. MerTK can be released from the cell surface by metalloproteinases, and this process is significantly enhanced when macrophages are stimulated e.g. with LPS. MerTK is often expressed on malignant cells, and may be implicated in immune evasion.

Details
Host Mouse
Isotype IgG1, kappa
Reactivity Human
Conjugate Purified
Reported Applications Immunohistochemical Staining, Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections
Documentation
TDS Link Download TDS
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References

References: Dransfield I, Zagórska A, Lew ED, Michail K, Lemke G. Mer receptor tyrosine kinase mediates both tethering and phagocytosis of apoptotic cells. Cell Death Dis. 2015 Feb 19;6:e1646.

Zagórska A, Través PG, Lew ED, Dransfield I, Lemke G. Diversification of TAM receptor tyrosine kinase function. Nat Immunol. 2014 Oct;15(10):920-8.

Zizzo G, Guerrieri J, Dittman LM, Merrill JT, Cohen PL. Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages,autoantibody specificities and disease activity. Arthritis Res Ther. 2013;15(6):R212. Zizzo G, Hilliard BA, Monestier M, Cohen PL. Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction. J Immunol. 2012 Oct 1;189(7):3508-20.

Prasad D, Rothlin CV, Burrola P, Burstyn-Cohen T, Lu Q, Garcia de Frutos P, Lemke G. TAM receptor function in the retinal pigment epithelium. Mol Cell Neurosci. 2006 Sep;33(1):96-108.

Stitt TN, Conn G, Gore M, Lai C, Bruno J, Radziejewski C, Mattsson K, Fisher J, Gies DR, Jones PF, et al. The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases. Cell. 1995 Feb 24;80(4):661-70.


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Area of BiologyCell TypeFormatsMiscellaneous