anti-human MadCAM-1

Description: This antigen is expressed in mucosal lymphoid tissue and lamina propria and is a counter-receptor for CD62L and CD49d. MAdCAM-1 is involved in homing of subpopulation of memory T cells to the gut lamina propria, and recirculation of naive lymphocytes in Peyer's patches and mesenteric lymph nodes.

The 1F3F3D4 antibody reacts with mouse tumor necrosis factor-alpha (TNF alpha), a 17 kDa cytokine produced by monocytes, macrophages, neutrophils, NK cells and CD4(+) T cells.

Citations: Rafiee,Parvaneh; Ogawa,Hitoshi; Heidemann,Jan; Li,Mona S.; Aslam,Mohammed; Lamirand,Thomas H.; Fisher,Pamela J.; Graewin,Shannon J.; Dwinell,Michael B.; Johnson,Christopher P.; Shaker,Reza; Binion,David G.. Isolation and characterization of human esophageal microvascular endothelial cells: mechanisms of inflammatory activation. Gastrointestinal and Liver Physiology 2003;285:G1277-G1292. (Link)

Ohman,L.; Isaksson,S.; Lundgren,A.; Simren,M.; Sjovall,H.. A Controlled Study of Colonic Immune Activity and @b7^+ Blood T Lymphocytes in Patients With Irritable Bowel Syndrome. Clinical Gastroenterology and Hepatology 2005;3:980-986. (Link)