Anti-Human LAP Functional Grade Purified

Description: This VB3A9 monoclonal antibody recognizes human latency-associated peptide (LAP), also known as the TGF-β propeptide. Human LAP is a homodimer of 65-75 kDa that is non-covalently associated with TGF-β and this complex is also referred to as the small latent complex (SLC). LAP can be covalently associated with latent TGF-β binding proteins (LTBP) through disulfide bonds, forming the large latent complex (LLC). The association of LAP with TGF-β facilitates its secretion and also renders TGF-β inactive.

VB3A9 has been reported to cross-react with non-human primate LAP, but does not cross-react with mouse LAP.

References: Annes JP, Chen Y, Munger JS, Rifkin DB. Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1. J Cell Biol. 2004 Jun 7;165(5):723-34. (VB3A9, WB, Pubmed)

Khalil N. TGF-beta: from latent to active. Microbes Infect. 1999 Dec;1(15):1255-63.

Munger JS, Huang X, Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, Pittet JF, Kaminski N, Garat C, Matthay MA, Rifkin DB, Sheppard D. The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell. 1999 Feb 5;96(3):319-28. (VB3A9, IP, simian, Pubmed).

Gleizes PE, Beavis RC, Mazzieri R, Shen B, Rifkin DB. Identification and characterization of an eight-cysteine repeat of the latent transforming growth factor-beta binding protein-1 that mediates bonding to the latent transforming growth factor-beta1. J Biol Chem. 1996 Nov 22;271(47):29891-6.