Human IL-9 Single-Use ELISA RSG Standard

Description: Interleukin-9 (IL-9) is a proinflammatory cytokine historically believed to be involved in type 2 immune responses. However, recent evidence suggests IL-9 may be secreted by a distinct T Helper lineage called Th9. These cells can either be derived from Th2 cells with TGF-β or differentiated directly from naïve CD4+ T cells with TGF-β and IL-4.

IL-9 is a member of the common cytokine receptor γ chain-dependent family of cytokines which also includes IL-2, IL-4, IL-7, IL-15 and IL-21. Its pleiotropic effects on Th2 lymphocytes, B lymphocytes, mast cells, eosinophils and gut and airway epithelial cells have implicated IL-9 in asthma and other allergy-related disorders.

References: Marc Veldhoen., et al. 2008. Transforming growth factor- 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset. Nature Immunology. Published online: 19 October 2008.

Matsuzawa, S., et al. 2003. IL-9 enhances the growth of human mast cell progenitors under stimulation with stem cell factor. J. Immun. 170: 3461-3467.

Nicolaides, N. C. et al. 1997. Interleukin 9: a candidate gene for asthma. Proc. Nat. Acad. Sci. 94: 13175-13180.

Kelleher, K. et al. 1991.Human interleukin-9: genomic sequence, chromosomal location, and sequences essential for its expression in human T-cell leukemia virus (HTLV)-I-transformed human T cells. Blood 77: 1436-1441.