Human IL-8 Recombinant Protein Carrier-Free

Also known as: Interleukin-8, 72aa

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 34-8089

Cat. No. Size
34-8089-82 100 ug
Please inquire about custom configurations or bulk packaging.

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Data for Human IL-8 Recombinant Protein Carrier-Free.

Description

Description: Human IL-8, also called neutrophil attractant/activating protein (NAP-1), monocyte derived neutrophil activating peptide (MONAP), monocyte derived neutrophil activating factor (ANF), monocyte derived neutrophil chemotactic factor (MDNCF), and neutophil activating factor (NAF), is a ~6-8 kDa factor produced by variety types of cells including monocytes, lymphocytes, granulocytes, fibroblasts and endothelial cells. IL-8 is an inflammatory cytokine which functions as a neutrophil chemoatractant and activating factor. It also attracts basophils and a subpopulation of lymphocytes.

Details
Reactivity Human
Purity > 98%, as determined by SDS-PAGE
Molecular Mass The protein is not methionylated at the N-terminal and has a predicted molecular mass of 8,386. The DTT reduced protein migrates as an 8 kDa polypeptide and the non-reduced polypeptide migrates as a 9kDa polypeptide on SDS-PAGE.
Endotoxin Level Less than 0.01 ng/ug cytokine as determined by the LAL assay.
Reported Applications Cytokine Bioassays
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
39-8089 Human IL-8 Single-Use ELISA RSG Standard ELISA RUO
14-8089 Human IL-8 Recombinant Protein FA RUO
References

References: Maheshwari A, Voitenok NN, Akalovich S, Shaik SS, Randolph DA, Sims B, Patel RP, Killingsworth CR, Fallon MB, Ohls RK. Developmental changes in circulating IL-8/CXCL8 isoforms in neonates. Cytokine. 2009 Apr;46(1):12-6.

Tajima A, Iwase T, Shinji H, Seki K, Mizunoe Y. Inhibition of endothelial interleukin-8 production and neutrophil transmigration by Staphylococcus aureus beta-hemolysin. Infect Immun. 2009 Jan;77(1):327-34.

Waugh DJ, Wilson C. The interleukin-8 pathway in cancer. Clin Cancer Res. 2008 Nov 1;14(21):6735-41.

Baggiolini M, Walz A, and Kunkel SL. Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils. J Clin Invest. 1989 Oct;84(4):1045-9.