Human IL-6 Platinum ELISA

Also known as: Interferon-beta 2, B-cell stimulatory factor 2,HGF

CE

SKU# BMS213/2CE*

Cat. No. Size
BMS213/2CE 96 tests
BMS213/2TENCE 10 x 96 tests
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Data for Human IL-6 Platinum ELISA.

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  • Data for Human IL-6 Platinum ELISA.
Description

Description: The human IL-6 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human IL-6. The human IL-6 ELISA is for in vitro diagnostic use. Not for use in therapeutic procedures.

Interleukin-6 (IL-6) is a multi-functional cytokine that regulates immune responses, acute phase reactions and hematopoiesis and may play a central role in host defense mechanisms. IL-6 is usually not produced constitutively by normal cells, but its expression is readily induced by a variety of cytokines, lipopolysaccharide (LPS) or viral infections. IL-6 is a pleiotropic cytokine produced by a variety of cells. It acts on a wide range of tissues, exerting growth-induction, growth-inhibition, and differentiation respectively, depending on the nature of the target cells.

IL-6 is involved in:

- the induction of B-cell differentiation
- the induction of acute phase proteins in liver cells
- growth promotion of myeloma/plasmacytoma/hybridoma cells
- induction of IL-2 and IL-2 receptor expression
- proliferation and differentiation of T cells
- inhibition of cell growth of certain myeloid leukemic cell lines and induction of their differentiation to macrophages
- enhancement of IL-3-induced multipotential colony cell formation in hematopoietic stem cells and induction of maturation of megakaryocytes as a thrombopoietic factor
- induction of mesangial cell growth
- induction of neural differentiation of PC 12 cells
- induction of keratinocyte growth

The abnormal production of IL-6 was first suggested to be related to polyclonal B-cell activation with autoantibody production in patients with cardiac myxoma. Since then, IL-6 has been suggested to be involved in the pathogenesis of a variety of diseases. Measurement of IL-6 levels in serum and other body fluids thus provides more detailed insights into various pathological situations.

Details
Reactivity Human
Sample Volume 50 uL
Suitable Sample Types cell culture supernatant, serum, plasma (EDTA, citrate, heparin)
Sensitivity 0.92 pg/mL
Standard Curve Range 1.56 - 100 pg/mL
Components Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to human IL-6
Biotin-Conjugate anti-human IL-6 monoclonal antibody
Streptavidin-HRP
Human IL-6 Standard, lyophilized, 200 pg/mL upon reconstitution
Control high
Control low
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Blue-Dye
Green-Dye
Red-Dye
Adhesive Films
Reported Applications ELISA
Documentation
TDS Link Download TDS
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References

Citations: Boucharaba,Ahmed; Serre,Claire Marie; Guglielmi,Julien; Bordet,Jean Claude; Clezardin,Philippe; Peyruchaud,Olivier. The type 1 lysophosphatidic acid receptor is a target for therapy in bone metastases. Proceedings of the National Academy of Sciences U.S.A. 2006;103:9643-9648. (Link)

Z”ller,Nadja Nicole; Kippenberger,Stefan; Tha‡i,Diamant; Mewes,Karsten; Spiegel,Martina; S„ttler,Andrea; Schultz,Maike; Bereiter-Hahn,Jrgen; Kaufmann,Roland; Bernd,August. Evaluation of beneficial and adverse effects of glucocorticoids on a newly developed full-thickness skin model. Toxicology in Vitro 2008;22:747-759. (Link)

Creely,Steven James; McTernan,Philip Gerard; Kusminski,Christine Maria; Fisher,ffolliot Martin; Khanolkar,Manish; Evans,Mark; Harte,Alison louise; Kumar,Sudhesh. Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes. Endocrinology and Metabolism 2006;292:00302(Link)

Piconi,L.; Quagliaro,L.; Da Ros,R.; Assaloni,R.; Giugliano,D.; Esposito,K.; Szabo,C.; Ceriello,A.. Intermittent high glucose enhances ICAM-1, VCAM-1, E-selectin and interleukin-6 expression in human umbilical endothelial cells in culture: the role of poly(ADP-ribose) polymerase. Journal of Thrombosis and Haemostasis 2004;2:1453-1459. (Link)

Stoeck,K.; Bodemer,M.; Zerr,I.. Pro- and anti-inflammatory cytokines in the CSF of patients with Creutzfeldt-Jakob disease. Journal of Neuroimmunology 2006;172:175-181. (Link)

Weigand,Markus A.; Schmidt,Heinfried; Zhao,Qingyu; Plaschke,Konstanze; Martin,Eike; Bardenheuer,Hubert J.. Ketamine Modulates the Stimulated Adhesion Molecule Expression on Human Neutrophils In Vitro. Anesthesia & Analgesia 2000;90:206(Link)

Gitto,E.; Romeo,C.; Reiter,R.J.; Impellizzeri,P.; Pesce,S.; Basile,M.; Antonuccio,P.; Trimarchi,G.; Gentile,C.; Barberi,I.. Melatonin reduces oxidative stress in surgical neonates. Journal of Pediatric Surgery 2004;39:184-189. (Link)

Xiao,Jing; Leung,Joseph C.K.; Chan,Loretta Y.Y.; Guo,Hong; Lai,Kar Neng. Protective effect of peroxisome proliferator-activated receptor-gamma agonists on activated renal proximal tubular epithelial cells in IgA nephropathy. Nephrology Dialysis Transplantation 2009;(Link)

Karth,Georg Delle; Buberl,Anton; Nikfardjam,Mariam; Meyer,Brigitte; Wollenek,Gregor; Grimm,Michael; Lassnigg,Andrea; Brannath,Werner; Hiesmayr,Michael; Heinz,Gottfried. Role of amiodarone on the systemic inflammatory response induced by cardiac surgery: proinflammatory actions: [Role de l'amiodarone sur la reaction inflammatoire systemique provoquee par la chirurgie cardiaque : actions pro-inflammatoires]. Canadian Journal of Anesthesia 2007;54:262-268. (Link)

Setola,Emanuela; Losa,Marco; Lanzi,Roberto; Lucotti,Pietro; Monti,Lucilla D.; Castrignano,Tristana; Galluccio,Elena; Giovanelli,Massimo; Piatti,PierMarco. Increased insulin-stimulated endothelin-1 release is a distinct vascular phenotype distinguishing Cushing's disease from metabolic syndrome. Clinical Endocrinology 2007;66:586-592. (Link)

Stefanska,Anna; Sypniewskay,Grazyna; Senterkiewicz,Lilla. Inflammatory Markers and Cardiovascular Risk in Healthy Polish Women across the Menopausal Transition. Clinical Chemistry 2005;51:1893-1895. (Link)

Niessner,A.; Richter,B.; Penka,M.; Steiner,S.; Strasser,B.; Ziegler,S.; Heeb-Elze,E.; Zorn,G.; Leitner-Heinschink,A.; Niessner,C.. Endurance training reduces circulating inflammatory markers in persons at risk of coronary events: Impact on plaque... Atherosclerosis 2006;186:160-165. (Link)

Ballinger,A.B.; Woolley,J.A.; Ahmed,M.; Mulcahy,H.; Alstead,E.M.; Landon,J.; Clark,M.L.; Farthing,M.J.G.. Persistent systemic inflammatory response after stent insertion in patients with malignant bile duct obstruction. Gut 1998;42:555-559. (Link)

Lam,Man Fai; Leung,Joseph C.K.; Lo,Wai Kei; Tam,Sidney; Chong,Mei ching; Lui,Sing Leung; Tse,Kai Chung; Chan,Tak Mao; Lai,Kar Neng. Hyperleptinaemia and chronic inflammation after peritonitis predicts poor nutritional status and mortality in patients on peritoneal dialysis. Nephrology Dialysis Transplantation 2007;22:1445-1450. (Link)

Kythreotis,Prokopis; Kokkini,Ageliki; Avgeropoulou,Stavrina; Hadjioannou,Argyro; Anastasakou,Efgenia; Rasidakis,Antonis; Bakakos,Petros. Plasma leptin and insulin-like growth factor I levels during acute exacerbations of chronic obstructive pulmonary disease. BMC Pulmonary Medicine 2009;9:11(Link)

Messalli,E.M.; Mainini,G.; Scaffa,C.; Cafiero,A.; Salzillo,P.L.; Ragucci,A.; Cobellis,L.. Raloxifene therapy interacts with serum osteoprotegerin in postmenopausal women. Maturitas 2007;56:38-44. (Link)

Lai,Kar Neng; Leung,Joseph C.K.; Chan,Loretta Y.Y.; Saleem,Moin A.; Mathieson,Peter W.; Lai,Fernand M.; Tang,Sydney C.W.. Activation of podocytes by mesangial-derived TNF-{alpha}: glomerulo-podocytic communication in IgA nephropathy. Renal Physiology 2008;294:F945-F955. (Link)

Genesca,Joan; Segura,Rosa; Gonzalez,Antonio; Catalan,Robert; Marti,Ramon; Torregrosa,Mireia; Cereto,Ferran; Martinez,Moises; Esteban,Rafael; Guardia,Jaime. Nitric oxide may contribute to nocturnal hemodynamic changes in cirrhotic patients. The American Journal of Gastroenterology 2000;95:1539-1544. (Link)

Cao,Huibi; Wang,Anan; Martin,Bernard; Koehler,David; Zeitlin,Pamela; Tanawell,A.; Hu,Jim. Down-regulation of IL-8 expression in human airway epithelial cells through helper-dependent adenoviral-mediated RNA interference. Cell Res 2005;15:111-119. (Link)

Schonbeck,Uwe; Gerdes,Norbert; Varo,Nerea; Reynolds,Rebecca S.; Horton,Daniel B.; Bavendiek,Udo; Robbie,Linda; Ganz,Peter; Kinlay,Scott; Libby,Peter. Oxidized Low-Density Lipoprotein Augments and 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Limit CD40 and CD40L Expression in Human Vascular Cells. Circulation 2002;106:2888-2893. (Link)

Fito,M.; Cladellas,M.; de la Torre,R.; Marti,J.; Munoz,D.; Schroder,H.; Alcantara,M.; Pujadas-Bastardes,M.; Marrugat,J.; Lopez-Sabater,M.; Bruguera,J.; Covas,M.. Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: a randomized, crossover, controlled trial. Eur J Clin Nutr 2007;doi: 10.10:(Link)

Targher,Giovanni; Zenari,Luciano; Bertolini,Lorenzo; Muggeo,Michele; Zoppini,Giacomo. Elevated Levels of Interleukin-6 in Young Adults With Type 1 Diabetes Without Clinical Evidence of Microvascular and Macrovascular Complications. Diabetes Care 2001;24:956-957. (Link)

Chan,Wai Long; Leung,Joseph; Chan,Loretta; Tam,K.; Tang,Sydney; Lai,Kar Neng. BMP-7 protects mesangial cells from injury by polymeric IgA. Kidney Int 2008;74:1026-1039. (Link)

Buchweitz,O.; Matthias,S.; Muller-Steinhardt,M.; Malik,E.. Laparoscopy in patients over 60 years old: A prospective, randomized evaluation of laparoscopic versus open adnexectomy. American Journal of Obstetrics and Gynecology 2005;193:1364-1368. (Link)

Mazzei,Valerio; Nasso,Giuseppe; Salamone,Giovanni; Castorino,Filippo; Tommasini,Antonello; Anselmi,Amedeo. Prospective Randomized Comparison of Coronary Bypass Grafting With Minimal Extracorporeal Circulation System (MECC) Versus Off-Pump Coronary Surgery. Circulation 2007;116:1761-1767. (Link)

Fiane,Arnt E.; Videm,Vibeke; Lingaas,Per S.; Heggelund,Lars; Nielsen,Erik W.; Geiran,Odd R.; Fung,Michael; Mollnes,Tom E.. Mechanism of Complement Activation and Its Role in the Inflammatory Response After Thoracoabdominal Aortic Aneurysm Repair. Circulation 2003;108:849-856. (Link)

Maczynska,Iwona; Millo,Barbara; Ratajczak-StefaDska,Violetta; Maleszka,Romuald; Szych,Zbigniew; Kurpisz,Maciej; Giedrys-Kalemba,Stefania. Proinflammatory cytokine (IL-1beta, IL-6, IL-12, IL-18 and TNF-alpha) levels in sera of patients with subacute cutaneous lupus erythematosus (SCLE). Immunology letters 2006;102:79-82. (Link)

Sacanella,Emilio; Vazquez-Agell,Monica; Mena,Mari Pau; Antunez,Emilia; Fernandez-Sola,Joaquim; Nicolas,Jose Maria; Lamuela-Raventos,Rosa M.; Ros,Emilio; Estruch,Ramon. Down-regulation of adhesion molecules and other inflammatory biomarkers after moderate wine consumption in healthy women: a randomized trial. American Journal of Clinical Nutrition 2007;86:1463-1469. (Link)

Rottner,Mathilde; Kunzelmann,Corinne; Mergey,Martine; Freyssinet,Jean Marie; Martinez,Maria Carmen. Exaggerated apoptosis and NF-{kappa}B activation in pancreatic and tracheal cystic fibrosis cells. FASEB Journal 2007;fj(Link)

Esmaillzadeh,Ahmad; Azadbakht,Leila. Home use of vegetable oils, markers of systemic inflammation, and endothelial dysfunction among women. American Journal of Clinical Nutrition 2008;88:913-921. (Link)

del Fresno,Carlos; Soler-Rangel,Llanos; Soares-Schanoski,Alessandra; Gomez-Pina,Vanesa; Gonzalez-Leon,Maria Carmen; Gomez-Garcia,Lourdes; Mendoza-Barbera,Elena; Rodriguez-Rojas,Alexandro; Garcia,Felipe; Fuentes-Prior,Pablo; Arnalich,Francisco; Lopez-Collazo,Eduardo. Inflammatory responses associated with acute coronary syndrome up-regulate IRAK-M and induce endotoxin tolerance in circulating monocytes. Journal of Endotoxin Research 2007;13:39-52. (Link)

Leung,Joseph C.K.; Tang,Sydney C.W.; Chan,Loretta Y.Y.; Chan,Wai Long; Lai,Kar Neng. Synthesis of TNF-{alpha} by mesangial cells cultured with polymeric anionic IgA role of MAPK and NF-{kappa}B. Nephrology Dialysis Transplantation 2008;23:72-81. (Link)

Chang,Yi Chung; Kao,Wei Chen; Wang,Wei Ya; Wang,Wan Yi; Yang,Ruey Bing; Peck,Konan. Identification and characterization of oligonucleotides that inhibit Toll-like receptor 2-associated immune responses. FASEB Journal 2009;fj(Link)

Syed,Akheel; Redfern,Christopher P.F.; Weaver,Jolanta. In Vivo and In Vitro Glucocorticoid Sensitivity in Obese People With Cushingoid Appearance. Obesity 2008;16:2374-2378. (Link)

Izadpanah,F.; Mojtahedzadeh,M.; Kazem Aghamir,S.M.; Atharikia,D.; Dashti,S.; Abbasi,A.. Effect of intravenous pentoxifylline in inflammatory response in patients undergoing nephrolithotomy. J Endourol. 2009;23:323-328. (Link)

Kubala,L.; Ruzickova,J.; Nickova,K.; Sandula,J.; Ciz,M.; Lojek,A.. The effect of (1->3)-. Carbohydrate Research 2003;338:2835-2840. (Link)

Schr”der,Anja K.; von der Ohe,Maren; Kolling,Ute; Altstaedt,Julia; Uciechowski,Peter; Fleischer,Daniela; Dalhoff,Klaus; Ju,Xinsheng; Zenke,Martin; Heussen,Nicole; Rink,Lothar. Polymorphonuclear leucocytes selectively produce anti-inflammatory interleukin-1 receptor antagonist and chemokines, but fail to produce pro-inflammatory mediators. Immunology 2006;119:317-327. (Link)

Wojakowski,Wojciech; Tendera,Michal; Michalowska,Anna; Majka,Marcin; Kucia,Magdalena; Maslankiewicz,Katarzyna; Wyderka,Rafal; Ochala,Andrzej; Ratajczak,Mariusz Z.. Mobilization of CD34/CXCR4+, CD34/CD117+, c-met+ Stem Cells, and Mononuclear Cells Expressing Early Cardiac, Muscle, and Endothelial Markers Into Peripheral Blood in Patients With Acute Myocardial Infarction. Circulation 2004;110:3213-3220. (Link)

Tang,Sydney C.W.; Leung,Joseph C.K.; Chan,Loretta Y.Y.; Tsang,Anita W.L.; Lai,Kar Neng. Activation of Tubular Epithelial Cells in Diabetic Nephropathy and the Role of the Peroxisome Proliferator-Activated Receptor-{gamma} Agonist. Journal of the American Society of Nephrology 2006;17:1633-1643. (Link)

Courtney,Harry S.; Ofek,Itzhak; Hasty,David L.. M protein mediated adhesion of M type 24 Streptococcus pyogenes stimulates release of interleukin-6 by HEp-2 tissue culture cells. FEMS Microbiology Letters 1997;151:65-70. (Link)

Napolitano,M.; Bravo,E.. Lipid metabolism and TNF-alpha secretion in response to dietary sterols in human monocyte derived macrophages. European Journal of Clinical Investigation 2005;35:482-490. (Link)

Ceriello,Antonio; Assaloni,Roberta; Da Ros,Roberto; Maier,Amabile; Piconi,Ludovica; Quagliaro,Lisa; Esposito,Katherine; Giugliano,Dario. Effect of Atorvastatin and Irbesartan, Alone and in Combination, on Postprandial Endothelial Dysfunction, Oxidative Stress, and Inflammation in Type 2 Diabetic Patients. Circulation 2005;111:2518-2524. (Link)

Saberi,Farzad; Heyland,Daren; Lam,Miu; Rapson,Dilys; Jeejeebhoy,Khursheed. Prevalence, Incidence, and Clinical Resolution of Insulin Resistance in Critically Ill Patients: An Observational Study. Journal of Parenteral and Enteral Nutrition 2008;32:227-235. (Link)

MONSINJON,T.I.P.H.; GASQUE,P.H.I.L.; CHAN,P.H.I.L.; ISCHENKO,A.L.E.X.; BRADY,JENNIFER J.; FONTAINE,M.A.R.C.. Regulation by complement C3a and C5a anaphylatoxins of cytokine production in human umbilical vein endothelial cells. FASEB Journal 2003;17:1003-1014. (Link)

Gruber,H.J.; Mayer,C.; Mangge,H.; Fauler,G.; Grandits,N.; Wilders-Truschnig,M.. Obesity reduces the bioavailability of nitric oxide in juveniles. Int.J.Obes.(Lond) 2008;32:826-831. (Link)

HIESMAYR,M.J.; SPITTLER,A.; LASSNIGG,A.; BERGER,R.; LAUFER,G.; KOCHER,A.; ARTEMIOU,O.; BOLTZ-NITULESCU,G.; ROTH,E.. Alterations in the number of circulating leucocytes, phenotype of monocyte and cytokine production in patients undergoing cardiothoracic surgery. Clinical and Experimental Immunology 1999;115:315-323. (Link)

Karrer,S.; Bosserhoff,A.K.; Weiderer,P.; Landthaler,M.; Szeimies,R.M.. Keratinocyte-derived cytokines after photodynamic therapy and their paracrine induction of matrix metalloproteinases in fibroblasts. British Journal of Dermatology 2004;151:776-783. (Link)

Hill,Eric J.; Vernallis,Ann B.. Polarized secretion of Leukemia Inhibitory Factor. BMC Cell Biology 2008;9:53(Link)

Radaelli,Alberto; Loardi,Claudia; Cazzaniga,Maria; Balestri,Giulia; DeCarlini,Caterina; Cerrito,M.Grazia; Cusa,Elena Negro; Guerra,Luca; Garducci,Stefano; Santo,Danilo; Menicanti,Lorenzo; Paolini,Giovanni; Azzellino,Arianna; Lavitrano,Maria Luisa; Mancia,Giuseppe; Ferrari,Alberto U.. Inflammatory Activation During Coronary Artery Surgery and Its Dose-Dependent Modulation by Statin/ACE-Inhibitor Combination. Arteriosclerosis, Thrombosis, and Vascular Biology 2007;27:2750-2755. (Link)

Michlmayr A.,S.Baumann,M.Zellner,C.Burghuber,P.Schuch,C.Wenzel,R.Bartsch,U.Pluschnig,I.Rech-Weichselbraun,G.Steger,R.Jakesz,M.Gnant and T.Bachleitner-Hofmann,M.Bergmann,R.Oehler. Chemotherapy induces inflammatory response in breast cancer patients. Keystonesymposia, Inflammation, Microenvironment and Cancer 2008;

Breitkreutz,I.; Raab,M.; Vallet,S.; Hideshima,T.; Raje,N.; Mitsiades,C.; Chauhan,D.; Okawa,Y.; Munshi,N.; Richardson,P.; Anderson,K.. Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma. Leukemia 2008;22:1925-1932. (Link)

Kanda,Junya; Mizumoto,Chisaki; Kawabata,Hiroshi; Tsuchida,Hideyuki; Tomosugi,Naohisa; Matsuo,Keitaro; Uchiyama,Takashi. Serum hepcidin level and erythropoietic activity after hematopoietic stem cell transplantation. Haematologica 2008;93:1550-1554. (Link)

Gitto,Eloisa; Reiter,Russel J.; Sabatino,Giuseppe; Buonocore,Giuseppe; Romeo,Carmelo; Gitto,Placido; Bugge,Concetta; Trimarchi,Giuseppe; Barberi,Ignazio. Correlation among cytokines, bronchopulmonary dysplasia and modality of ventilation in preterm newborns: improvement with melatonin treatment. Journal of Pineal Research 2005;39:287-293. (Link)

Kalambokis,Georgios; Kostoula,Ageliki; Economou,Michalis; Tsianos,Epameinondas V.. Tumor Necrosis Factor-{alpha}-Related Intraperitoneal Release of CA 125 in Cirrhotic Patients with Sterile Ascites. Clinical Chemistry 2005;51:2207-2208. (Link)

Szerafin,Tamas; Hoetzenecker,Konrad; Hacker,Stefan; Horvath,Ambrus; Pollreisz,Andreas; Arpad,Peterffy; Mangold,Andreas; Wliszczak,Tina; Dworschak,Martin; Seitelberger,Rainald; Wolner,Ernst; Ankersmit,Hendrik J.. Heat Shock Proteins 27, 60, 70, 90{alpha}, and 20S Proteasome in On-Pump Versus Off-Pump Coronary Artery Bypass Graft Patients. Annals of Thoracic Surgery 2008;85:80-87. (Link)

Pacheco-Castro,Alberto; Alvarez-Zapata,David; Serrano-Torres,Pilar; Regueiro,Jose R.. Signaling Through a CD3{gamma}-Deficient TCR/CD3 Complex in Immortalized Mature CD4+ and CD8+ T Lymphocytes. The Journal of Immunology 1998;161:3152-3160. (Link)

Wojakowski,Wojciech; Tendera,Michal; Zebzda,Anna; Michalowska,Anna; Majka,Marcin; Kucia,Magdalena; Maslankiewicz,Katarzyna; Wyderka,Rafal; Krol,Marek; Ochala,Andrzej; Kozakiewicz,Krystyna; Ratajczak,Mariusz Z.. Mobilization of CD34+, CD117+, CXCR4+, c-met+ stem cells is correlated with left ventricular ejection fraction and plasma NT-proBNP levels in patients with acute myocardial infarction. European Heart Journal 2006;27:283-289. (Link)

Cignetti,Alessandro; Vallario,Antonella; Roato,Ilaria; Circosta,Paola; Allione,Bernardino; Casorzo,Laura; Ghia,Paolo; Caligaris-Cappio,Federico. Leukemia-Derived Immature Dendritic Cells Differentiate into Functionally Competent Mature Dendritic Cells That Efficiently Stimulate T Cell Responses. The Journal of Immunology 2004;173:2855-2865. (Link)

George,Isaac; Colley,Patrick; Russo,Mark J.; Martens,Timothy P.; Burke,Elizabeth; Oz,Mehmet C.; Deng,Mario C.; Mancini,Donna M.; Naka,Yoshifumi. Association of device surface and biomaterials with immunologic sensitization after mechanical support. The Journal of Thoracic and Cardiovascular Surgery 2008;135:1372-1379. (Link)

Gunaydin,Serdar; Farsak,Bora; Kocakulak,Mustafa; Sari,Tamer; Yorgancioglu,Cem; Zorlutuna,Yaman. Clinical performance and biocompatibility of poly(2-methoxyethylacrylate)--coated extracorporeal circuits. Annals of Thoracic Surgery 2002;74:819-824. (Link)

References: Helfgott,D.C.; Tatter,S.B.; Santhanam,U.; Clarick,R.H.; Bhardwaj,N.; May,L.T.; Sehgal,P.B.. Multiple forms of IFN-beta 2/IL-6 in serum and body fluids during acute bacterial infection. J.Immunol. 1989;142:948-953. (Link)

Ueyama,M.; Maruyama,I.; Osame,M.; Sawada,Y.. Marked increase in plasma interleukin-6 in burn patients. J.Lab Clin.Med. 1992;120:693-698. (Link)

May,L.T.; Santhanam,U.; Tatter,S.B.; Bhardwaj,N.; Ghrayeb,J.; Sehgal,P.B.. Phosphorylation of secreted forms of human beta 2-interferon/hepatocyte stimulating factor/interleukin-6. Biochem.Biophys.Res.Commun. 1988;152:1144-1150. (Link)

Martinez-Maza,O.. IL6 and AIDS. Res.Immunol. 1992;143:764-769. (Link)

Santhanam,U.; Avila,C.; Romero,R.; Viguet,H.; Ida,N.; Sakurai,S.; Sehgal,P.B.. Cytokines in normal and abnormal parturition: elevated amniotic fluid interleukin-6 levels in women with premature rupture of membranes associated with intrauterine infection. Cytokine 1991;3:155-163. (Link)

Nakajima,K.; Martinez-Maza,O.; Hirano,T.; Breen,E.C.; Nishanian,P.G.; Salazar-Gonzalez,J.F.; Fahey,J.L.; Kishimoto,T.. Induction of IL-6 (B cell stimulatory factor-2/IFN-beta 2) production by HIV. J.Immunol. 1989;142:531-536. (Link)

Cayphas,S.; Van,Damme J.; Vink,A.; Simpson,R.J.; Billiau,A.; Van,Snick J.. Identification of an interleukin HP1-like plasmacytoma growth factor produced by L cells in response to viral infection. J.Immunol. 1987;139:2965-2969. (Link)

Koj Aleksander. Regulation of the acute phase and immune responses: interleukin-6. Ann.N Y.Acad.Sci. 1989;557:1-583. (Link)

Hirano,T.; Matsuda,T.; Turner,M.; Miyasaka,N.; Buchan,G.; Tang,B.; Sato,K.; Shimizu,M.; Maini,R.; Feldmann,M.; .. Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur.J.Immunol. 1988;18:1797-1801. (Link)

Sheron,N.; Bird,G.; Goka,J.; Alexander,G.; Williams,R.. Elevated plasma interleukin-6 and increased severity and mortality in alcoholic hepatitis. Clin.Exp.Immunol. 1991;84:449-453. (Link)

Zilberstein,A.; Ruggieri,R.; Korn,J.H.; Revel,M.. Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines. EMBO J. 1986;5:2529-2537. (Link)

Helle,M.; Brakenhoff,J.P.; De Groot,E.R.; Aarden,L.A.. Interleukin 6 is involved in interleukin 1-induced activities. Eur.J.Immunol. 1988;18:957-959. (Link)

Pettersson,T.; Metsarinne,K.; Teppo,A.M.; Fyhrquist,F.. Immunoreactive interleukin-6 in serum of patients with B-lymphoproliferative diseases. J.Intern.Med. 1992;232:439-442. (Link)

Hirano,T.; Yasukawa,K.; Harada,H.; Taga,T.; Watanabe,Y.; Matsuda,T.; Kashiwamura,S.; Nakajima,K.; Koyama,K.; Iwamatsu,A.; .. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 1986;324:73-76. (Link)

Ray,A.; Tatter,S.B.; Santhanam,U.; Helfgott,D.C.; May,L.T.; Sehgal,P.B.. Regulation of expression of interleukin-6. Molecular and clinical studies. Ann.N Y.Acad.Sci. 1989;557:353-361. (Link)

May,L.T.; Ghrayeb,J.; Santhanam,U.; Tatter,S.B.; Sthoeger,Z.; Helfgott,D.C.; Chiorazzi,N.; Grieninger,G.; Sehgal,P.B.. Synthesis and secretion of multiple forms of beta 2-interferon/B-cell differentiation factor 2/hepatocyte-stimulating factor by human fibroblasts and monocytes. J.Biol.Chem. 1988;263:7760-7766. (Link)

Hirano,T.; Taga,T.; Nakano,N.; Yasukawa,K.; Kashiwamura,S.; Shimizu,K.; Nakajima,K.; Pyun,K.H.; Kishimoto,T.. Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2). Proc.Natl.Acad.Sci.U S A 1985;82:5490-5494. (Link)

Oka,Y.; Murata,A.; Nishijima,J.; Yasuda,T.; Hiraoka,N.; Ohmachi,Y.; Kitagawa,K.; Yasuda,T.; Toda,H.; Tanaka,N.; .. Circulating interleukin 6 as a useful marker for predicting postoperative complications. Cytokine 1992;4:298-304. (Link)

Horii,Y.; Iwano,M.; Hirata,E.; Shiiki,M.; Fujii,Y.; Dohi,K.; Ishikawa,H.. Role of interleukin-6 in the progression of mesangial proliferative glomerulonephritis. Kidney Int.Suppl 1993;39:S71-S75. (Link)

Ray,A.; Tatter,S.B.; Santhanam,U.; Helfgott,D.C.; May,L.T.; Sehgal,P.B.. Regulation of expression of interleukin-6. Molecular and clinical studies. Ann.N.Y.Acad.Sci. 1989;557:353-361. (Link)

Hirano,T.; Akira,S.; Taga,T.; Kishimoto,T.. Biological and clinical aspects of interleukin 6. Immunol.Today 1990;11:443-449. (Link)

Elder,J.T.; Sartor,C.I.; Boman,D.K.; Benrazavi,S.; Fisher,G.J.; Pittelkow,M.R.. Interleukin-6 in psoriasis: expression and mitogenicity studies. Arch.Dermatol.Res. 1992;284:324-332. (Link)

Merico,F.; Bergui,L.; Gregoretti,M.G.; Ghia,P.; Aimo,G.; Lindley,I.J.; Caligaris-Cappio,F.. Cytokines involved in the progression of multiple myeloma. Clin.Exp.Immunol. 1993;92:27-31. (Link)

Seguchi,T.; Yokokawa,K.; Sugao,H.; Nakano,E.; Sonoda,T.; Okuyama,A.. Interleukin-6 activity in urine and serum in patients with bladder carcinoma. J.Urol. 1992;148:791-794. (Link)

Hirano,T.; Taga,T.; Yasukawa,K.; Nakajima,K.; Nakano,N.; Takatsuki,F.; Shimizu,M.; Murashima,A.; Tsunasawa,S.; Sakiyama,F.; .. Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production. Proc.Natl.Acad.Sci.U.S.A 1987;84:228-231. (Link)


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