Anti-Human IL-23 p19 Functional Grade Purified

Description: The HNU2319 monoclonal antibody is specific to the p19 subunit of human IL-23, a heterodimeric cytokine made up of two covalently linked subunits, p40 and p19. It is closely related to IL-12, with which it shares the p40 subunit. Dendritic cells and macrophages produce IL-23 in response to TLR2, TLR4, and TLR8 ligands, as well as the β-glucan receptor Dectin-1.

Human IL-23 induces proliferation of memory T cells and induces moderate levels of IFN-γ production by naïve and memory T cells, as compared to IL-12. In contrast, the mouse IL-23 biological activities are more distinctly different than those of mouse IL-12 suggesting the signaling or response elements (receptors) differ between species. The IL-23 receptor is also heterodimeric and shares the IL-12Rβ1 chain with IL-12, while the IL-23R chain is unique to IL-23. Signaling occurs through the Jak/STAT pathway and results in RORγt expression, which drives the differentiation of CD4⁺ T-cells towards the Th17 phenotype.

The monoclonal antibody HNU2319 neutralizes the bioactivity of IL-23 without affecting IL-12.

References: Dennehy KM, Willment JA, Williams DL, Brown GD. Reciprocal regulation of IL-23 and IL-12 following co-activation of Dectin-1 and TLR signaling pathways. Eur J Immunol. 2009 May;39(5): 1379-86

Hillyen P, Larche MJ, Bowman EP, McClanahan TK, de Waal Malefyt R, Schewitz LP, Giddins G, Feldmann M, Kastelein RA, Brennan FM. Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis. Rheumatology. 2009; 48: 1581-9

Goriely S., Neurath MF., and Goldman M. How microorganisms tip the balance between interleukin-12 family members. Nat Rev Immunol. 2008 Jan;8(1):81-6