Anti-Human IL-21 Purified

Description: The rabbit polyclonal antibody reacts with human IL-21; the antibody was raised against a synthetic peptide (tcpscdsyekkppke) corresponding to amino acids 121 to 135 of human IL-21 precursor (1). A novel cytokine was recently identified in human and mouse and designated IL-21 (1), which has significant homology to IL-2, IL-4, and IL-15. The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family (1,2). IL-21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL-21 signaling (3,4). IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21 is expressed in activated T cells, and HL-60 and THP-1 cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.

References:
1. Parrish-Novak J, Dillon SR, Nelson A, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature. 2000;408(6808):57-63.
2. Ozaki K, Kikly K, Michalovich D, et al. Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. Proc Natl Acad Sci USA . 2000;97(21):11439-44.
3. Asao H, Okuyama C, Kumaki S, et al. the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J Immunol. 2001;167(1):1-5.
4. Vosshenrich CA, Di Santo JP. Cytokines: IL-21 joins the gamma(c)-dependent network? Curr Biol. 2001;11(5):R175-7.