Anti-Human IL-21 Alexa Fluor® 647 (To Be Discontinued. Refer to Replacement Format eFluor® 660, cat. 50-7219)

Also known as: Interleukin-21, IL21

Clone: eBio3A3-N2 (3A3-N2)

RUO: For Research Use Only. Not for use in diagnostic procedures.

Attention: To Be Discontinued. Refer to Replacement Format eFluor® 660 cat. 50-7219

SKU# 51-7219

Cat. No.	Size
51-7219-41	25 tests
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Intracellular staining of unstimulated (left) or PMA/ionomycin/monensin (5 hour) stimulated (right)...View More

Description

Description: The monoclonal antibody eBio3A3-N2 reacts with human IL-21, a potent stimulator of NK and cytolytic T cells. IL-21 is a 131 amino acid protein most closely related to IL-2 and IL-15. Expression is found in CD4+ cells upon activation. In addition to its effect on NK cells, IL-21 stimulates proliferation of B-cell stimulated by crosslinking of the CD40 antigen and stimulates the proliferation of bone marrow progenitor cells and the expression of the NK-cell marker CD56 in the presence of IL-15.

Details

Host	Mouse
Isotype	IgG1, kappa
Reactivity	Human
Conjugate	Alexa Fluor 647
Laser	Red Laser
Emit	668 nm
Excite	633 nm
Legal	Alexa Fluor® and Pacific Blue® are registered trademarks of and licensed under patents assigned to Molecular Probes, Inc. for research use only. This product is subject to an agreement between Molecular Probes, Inc. and eBioscience, and the manufacture, use, sale or import of this product may be subject to one or more U.S. patents, pending applications and corresponding foreign equivalents, owned by Molecular Probes, Inc. (a wholly owned subsidiary of Invitrogen Corp). The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product for life science research or as an ASR. The buyer cannot use this product for manufacturing or for any other screening (specifically including use in combination with microarrays or High Content Screening) or testing purpose, other than as an ASR. For information on purchasing a license to this product for purposes other than life science research or use as an ASR, contact Molecular Probes, Inc.
Reported Applications	Intracellular Staining Followed by Flow Cytometric Analysis

Documentation

For complete product information, please download the TDS or IFU document.

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
50-7219	Anti-Human IL-21 eFluor® 660	633 nm	668 nm	FC	RUO
12-7219	Anti-Human IL-21 PE	488 - 561 nm	575 nm	FC	RUO
14-7219	Anti-Human IL-21 Purified			ELISA	RUO

References

References: Parrish-Novak J, et al. 2000. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature. 408(6808):57-63.

Parrish-Novak J, et al. 2002. Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J Leukoc Biol. 72(5):856-63.

View More Products

Antigens	Area of Biology	Cell Type	Formats
IL-21	Adaptive Immunity Cytokines, Chemokines, Growth Factors	B Cells T Cells Th17 Cells Tfh Cells	Alexa Fluor 647