Human IL-20 Recombinant Protein

Description: IL-20 is a recently-discovered member of the IL-10 cytokine family. It is expressed by monocytes, dendritic cells, and keratinocytes. IL-20 activates STAT3 in target cells by activating either of two heterodimeric receptor complexes. One of these consists of IL-20Rβ and IL-20Rα and can be activated by IL-19 and IL-24 as well as IL-20. The other, a complex of IL-20Rβ and IL-22Rα, is activated only by IL-20 and IL-24. IL-20 induces the production of proinflammatory cytokines such as IL-1β, IL-6, and TNFα in monocytes and has been implicated in inflammatory conditions such as atherosclerosis, rheumatoid arthritis, and psoriasis. IL-20 also induces the proliferation of hematopoetic progenitor cells and keratinocytes

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Chen WY, Cheng BC, Jiang MJ, Hsieh MY, Chang MS. IL-20 is expressed in atheroscleroris plaques and promotes atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2006 Sep;26(9):2090-5.

Hsu YH, Li HH, Hsieh MY, Liu MF, Huang KY, Chin LS, Chen PC, Cheng HH, Chang MS. Function of interleukin-20 as a proinflammatory molecule in rheumatoid and experimental arthritis. Arthritis Rheum. 2006 Sep;54(9):2722-33.