Human IL-2 Platinum ELISA

Description: The human IL-2 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human IL-2. The human IL-2 ELISA is for research use only. Not for diagnostic or therapeutic procedures.

IL-2 plays a central role in the activation and proliferation of lymphocytes that have been primed by antigens. IL-2 plays a pivotal role in for the expansion of most T-cells, natural killer cells and B-cells during certain phases of their response. IL-2 is a 15 kDa glycoprotein encoded by a single gene located in the q26-28 region of human chromosome 4. The cDNA deduced polypeptide consists of 153 amino acids. Apart from its most important role to mediate antigen-specific T-lymphocyte proliferation, IL-2 modulates the expression of interferon gamma and major histocompatibility antigens, stimulates proliferation and differentiation of activated B-cells, augments natural killer cell activity and inhibits granulocyte-macrophage colony formation. IL-2 displays antitumoral effects, thus being used in cancer therapy. Monitoring of IL-2 levels in serum provides more detailed insights in several pathological situations such as cancer, infectious diseases, transplant rejection, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus and type I diabetes.

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Paccani,Silvia Rossi; Tonello,Fiorella; Ghittoni,Raffaella; Natale,Mariarita; Muraro,Lucia; D'Elios,Mario Milco; Tang,Wei Jen; Montecucco,Cesare; Baldari,Cosima T.. Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signaling. Journal of Experimental Medicine 2005;201:325-331. (Link)

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Gunaydin,Serdar; McCusker,Kevin; Vijay,Venkataramana; Isbir,Selim; Sari,Tamer; Onur,Mehmet Ali; Gurpinar,Aylin; Sezgin,Aysun; Sargon,Mustafa F.; Tezcaner,Tevfik; Zorlutuna,Yaman. Comparison of polymethoxyethylacrylate-coated circuits with leukocyte filtration and reduced heparinization protocol on heparin-bonded circuits in different risk cohorts. Perfusion 2006;21:329-342. (Link)

Gobert,Michael; Treilleux,Isabelle; Bendriss-Vermare,Nathalie; Bachelot,Thomas; Goddard-Leon,Sophie; Arfi,Vanessa; Biota,Cathy; Doffin,Anne Claire; Durand,Isabelle; Olive,Daniel; Perez,Solene; Pasqual,Nicolas; Faure,Christelle; Ray-Coquard,Isabelle; Puisieux,Alain; Caux,Christophe; Blay,Jean Yves; Menetrier-Caux,Christine. Regulatory T Cells Recruited through CCL22/CCR4 Are Selectively Activated in Lymphoid Infiltrates Surrounding Primary Breast Tumors and Lead to an Adverse Clinical Outcome. Cancer Research 2009;69:2000-2009. (Link)

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Cornaby,A.; Simpson,M.; Vann,Rice R.; Dempsey,R.; Madras,P.; Jenkins,R.; Monaco,A.. Interleukin 2 levels and urine cytology distinguish between cyclosporine toxicity and rejection in renal and liver allograft recipients. Transplant Proc. 1988;20:827-830. (Link)