Human IL-17A FlowCytomix Simplex

Description: This Human IL-17A FlowCytomix Simplex Kit is designed for the measurement of human IL-17A in a bead based immunoassay analyzed on a flow cytometer.

eBioscience bead-based immunoassays follow the same principle as a sandwich immunoassay.

Basic Kits include essential core reagents and are required to successfully perform assays using combinations of Simplex Kits.

The T help 1 (Th1) and Th2 cell classification has provided the framework for understanding CD4(+) T cell biology and the interplay between innate and adaptive immunity. Studies have defined an novel arm of the CD4(+) T cell effector response, the Th17 lineage. IL-17A, a homodimeric cytokine of about 32 kDa, is largely produced by activated memory T lymphocytes, but stimulates innate immunity and host defense. The closest associate to IL-17A is IL-17F, which is encoded in a syntenic fashion and shares around 50% sequence homology. IL-17A and IL-17F both mobilize neutrophils partly through granulopoeisis and CXC chemokine induction.

Increased levels of IL-17 have been associated with several conditions, including airway inflammation, rheumatoid arthritis, intraperitoneal abscesses and adhesions, inflammatory bowel disease, allograft rejection, psoriasis, cancer and multiple sclerosis.

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