Human IL-16 Recombinant Protein

Description: Interleukin 16 (IL-16), also called LCF, is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. The native IL-16 is a proteolytic cleavage product of the pro-IL-16 generated by proteases present in or on activated CD8+ cells. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4 + T cells. Human and mouse IL-16 have significant cross reactivity.

References: Baier, M., et al. 1997. Molecular cloning, sequence, expression, and processing of the interleukin 16 precursor. Proc. Nat. Acad. Sci. 94: 5273-5277.

Bandeira-Melo, C., et al. 2002. IL-16 promotes leukotriene C4 and IL-4 release from human eosinophils via CD4- and autocrine CCR3-chemokine-mediated signaling. J. Immun. 168: 4756-4763.

Cruikshank, W. W., et al. 1994. Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression. Proc. Nat. Acad. Sci. 91: 5109-5113.

Keane, J., et al. 1998. Conservation of structure and function between human and murine IL-16. J. Immun. 160: 5945-5954.

Lynch, E. A., et al. 2003. Cutting edge: IL-16/CD4 preferentially induces Th1 cell migration: requirement of CCR5. J. Immun. 171: 4965-4968.