Anti-Human IL-15 Functional Grade Purified

Description: The ct2nu monoclonal antibody reacts with human IL-15 and neutralizes its bioactivity. IL-15, or IL-T, is a 14 kDa proinflammatory cytokine and member of the IL-2 family. It plays a role in the development and maturation of macrophages and dendritic cells, and is essential to the proliferation and survival of NK cells and CD8⁺ T cells.

IL-15 is expressed by antigen-presenting cells, epithelial cells, and stromal cells. IL-15 activates the Jak/STAT pathway through its heterotrimeric receptor. Two subunits of this receptor, the β and γ chains, are shared with the rest of the family, while the α subunit is unique to IL-15. In mice, the α chain is required to chaperone IL-15 from the ER to secretion. This chaperoning is not necessary in humans, and free IL-15 is detectable in human biological samples. However, the receptor-cytokine complex has been indentified in humans and demonstrates agonistic activity several-fold higher than IL-15 alone.

References: Fehniger TA and Caligiuri MA. Interleukin 15: biology and relevance to human disease. Blood 2001 Jan 1: 97(1): 14-32.

Huntington ND, Legrand N, Alves NL, Jaron B, Weijer K, Plet A, Corcuff E, Mortier E, Jacques Y, Spits H, Di Santo JP. IL-15 trans-presentation promotes human NK cell development and differentiation in vivo. J Exp Med. 2009 Jan 16; 206(1): 25-34.

Rowley J, Archana M, Chien-Fu H, Wu TC. Inhibition of tumor growth by NK1.1+ and CD8+ T cells activated by IL-15 through receptor betagamma signaling in trans. J Immunol. 2008; 181: 8237-47.