anti-human IL-10

Description: IL-10 (BT-10) is a mouse monoclonal antibody raised against IL-10 of human origin. BMS 131/2 is recommended for detection of IL-10 of human origin by solid phase ELISA.

Interleukin-10 is a regulator of lymphoid and myeloid cell function. In humans IL-10 is produced by activated CD8(+) peripheral blood T-cells, by T-helper CD4(+) T-cell clones.
Due to the ability of IL-10 to block cytokine synthesis and several accessory cell functions of macrophages this cytokine is a potent suppressor of the effector functions of macrophages, T-cells and NK cells. In addition, IL-10 participates in regulating proliferation and differentiation of B-cells, mast cells and thymocytes. The corresponding protein exerts 160 amino acids with a predicted molecular mass of 18.5 kDa. Based on its primary structure, IL-10 is a member of the four a-helix bundle family of cytokines. In solution human IL-10 is a homodimer with an apparent molecular mass of 39 kDa. Although it contains an N-linked, glycosylation site, it lacks detectable carbohydrates. The immunosuppressive properties of IL-10 suggest a possible clinical use of IL-10 in suppressing rejections of grafts after organ transplantations. IL-10 can furthermore exert strong anti-inflammatory activities.

Citations: Casnici,C.; Lattuada,D.; Franco,P.; Cattaneo,L.; Marelli,O.. Regulation of human peripheral blood lymphocytes IL-10 BY SMS 201-995. Journal of Neuroimmunology 2004;149:210-216. (Link)

Vermi,William; Facchetti,Fabio; Riboldi,Elena; Heine,Holger; Scutera,Sara; Stornello,Sarah; Ravarino,Daniela; Cappello,Paola; Giovarelli,Mirella; Badolato,Raffaele; Zucca,Mario; Gentili,Francesca; Chilosi,Marco; Doglioni,Claudio; Ponzi,Alessandro Negro; Sozzani,Silvano; Musso,Tiziana. Role of dendritic cell-derived CXCL13 in the pathogenesis of Bartonella henselae B-rich granuloma. Blood 2006;107:454-462. (Link)