Human IGF-2 Recombinant Protein

Also known as: Insulin-like Growth Factor 2, IGF-II, somatomedin A

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 14-8505

Cat. No. Size
14-8505-62 5 ug
14-8505-80 25 ug
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Data for Human IGF-2 Recombinant Protein.

Description

Description: Insulin-like growth factor II (IGF-2), also known as somatomedin A, is a member of the insulin-like growth factor family expressed in many cell types and is secreted into the blood. IGF-2 is a potent mitogen and plays an important role in embryonic development. IGF-2 also plays important roles in obesity and tumor pathogenesis. IGF-1 and IGF-2 share 70% sequence identity. IGF-2 is 100% identical among human, bovine and porcine and exhibits cross-species activity. Recombinant Human IGF-2 produced in E.coli is a single, non-glycosylated, polypeptide chain containing 67 amino acids and having a molecular mass of 7.5 kDa.

Details
Reactivity Human
Purity Greater than 97%, as determined by SDS-PAGE
Endotoxin Level Less than 0.01 ng/ug cytokine as determined by the LAL assay.
Reported Applications Cytokine Bioassays
Documentation

For complete product information, please download the TDS or IFU document.

TDS Link Download TDS
Additional Formats
References

References: Riccio A, Sparago A, Verde G, De Crescenzo A, Citro V, Cubellis MV, Ferrero GB, Silengo MC, Russo S, Larizza L, Cerrato F. Inherited and Sporadic Epimutations at the IGF2-H19 locus in Beckwith-Wiedemann syndrome and Wilms' tumor. Endocr Dev. 2009; 14:1-9.

Sakatani, T. Kaneda, A. Iacobuzio-Donahue, C. A. Carter, M. G. de Boom Witzel, S. Okano, H. Ko, M. S. H. Ohlsson, R. Longo, D. L. Feinberg, A. P. Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. Science 2005; 307: 1976-1978.

Bachner-Melman, R. Zohar, A. H. Nemanov, L. Heresco-Levy, U. Gritsenko, I. Ebstein, R. P. Association between the insulin-like growth factor 2 gene (IGF2) and scores on the Eating Attitudes Test in nonclinical subjects: a family-based study. Am. J. Psychiat. 2005; 162: 2256-2262.

Gaunt, T. R. Cooper, J. A. Miller, G. J. Day, I. N. M. O'Dell, S. D. Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males. Hum. Molec. Genet. 2001; 10: 1491-1501.