Anti-Human IgE PE

Description: The monoclonal antibody IgE21 recognizes the immunoglobulin E class of antibodies. The natural levels of IgE in the serum are quite low, comprising only a small portion of the total immunoglobulin. IgE plays a role in allergy responses by binding to mast cells and basophils through the Fcε receptor I which results in the release of histamine and other molecules. The IgE is produced by terminally differentiated plasma B cells and basophils. Like all immunoglobulins, IgE is expressed as a soluble molecule as well as a membrane bound form. IgE21 recognizes both forms.

References: Sainte-Laudy J, Belon P. Use of four different flow cytometric protocols for the analysis of human basophil activation. Application to the study of the biological activity of high dilutions of histamine. Inflamm. res. 55, Supplement 1. 2006;S23-S24. (FC)

Chang TW, Davis F, Sun N, Sun C, MacGlashan D, Hamilton R. Monoclonal antibodies specific for human IgE-producing B cells: a potential therapeutic for IgE-mediated allergies. NPG Bio/technology. 1990 Feb;8:122-126.