Recombinant Human IFN-gamma

Also known as: Immune interferon, IFG

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# BMS303*

Cat. No. Size
BMS303 110 ug
Please inquire about custom configurations or bulk packaging.

To enable ordering, please select your country. Cookies will need to be enabled to continue on our website. View our Privacy Policy.

Description

Description: Recombinant Human IFN-gamma produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 144 amino acids and having a molecular mass of 16879 Dalton.

IFN-gamma, also called Type II interferon, is a homodimeric glycoprotein containing approximately 21 to 24 kD subunits. The human IFN-gamma gene, situated on chromosome 12, contains three introns; the four exons code for a polypeptide of 166 amino acids, 20 of which constitute the signal peptide. In contrast to IFN-alpha and IFN-beta synthesis, which can occur in any cell, production of IFN-gamma is a function of T cells and NK cells.

IFN-gamma has antiviral and antiparasitic activities and also inhibits the proliferation of a number of normal and transformed cells. IFN-gamma synergises with TNF-alpha and TNF-beta in inhibiting the proliferation of various cell types.

Details
Reactivity Human
Components 1 vial (110 ug) human IFN-gamma
Purity >98% pure prior to addition of human serum albumin
Molecular Mass 33.0 kDa
Reported Applications Flow Cytometric Analysis, ELISA
Documentation
TDS Link Download TDS
Related Products
Cat. No. Name Excite Emit Application Reg.
14-8018 Human IL-1 beta Recombinant Protein ELISA, FA RUO
14-8185 B18R Recombinant Protein FA RUO
14-8339 Human GM-CSF Recombinant Protein ELISA, FA RUO
14-8986 Human FGF basic (FGF-2) Recombinant Protein FA RUO
BMS305* Recombinant Human IFN-alpha2c FC, ELISA RUO
References

Citations: Allende,Luis M.; Lopez-Goyanes,Alberto; Paz-Artal,Estela; Corell,Alfredo; Garcia-Perez,M.Angel; Varela,Pilar; Scarpellini,Atilio; Negreira,Sagrario; Palenque,Elia; Arnaiz-Villena,Antonio. A Point Mutation in a Domain of Gamma Interferon Receptor 1 Provokes Severe Immunodeficiency. Clinical and Diagnostic Laboratory Immunology 2001;8:133-137. (Link)

Vogl,Thomas; Tenbrock,Klaus; Ludwig,Stephan; Leukert,Nadja; Ehrhardt,Christina; van Zoelen,Marieke; Nacken,Wolfgang; Foell,Dirk; van der Poll,Tom; Sorg,Clemens; Roth,Johannes. Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat Med 2007;advanced o:1042-1049. (Link)

Johansson,Catharina; Eshaghi,Hojjat; Linder,Maria; Jakobson,Eva; Scheynius,Annika. Positive Atopy Patch Test Reaction to Malassezia furfur in Atopic Dermatitis Correlates with a T Helper 2-like Peripheral Blood Mononuclear Cells Response. Journal of Investigative Dermatology 2002;118:1044-1051. (Link)

Masjedi,K.; Ahlborg,N.; Gruvberger,B.; Bruze,M.; Karlberg,A.T.. Methylisothiazolinones elicit increased production of both T helper (Th)1- and Th2-like cytokines by peripheral blood mononuclear cells from contact allergic individuals. British Journal of Dermatology 2003;149:1172-1182. (Link)

Minang,J.T.; Troye-Blomberg,M.; Lundeberg,L.; Ahlborg,N.. Nickel Elicits Concomitant and Correlated in vitro Production of Th1-, Th2-Type and Regulatory Cytokines in Subjects with Contact Allergy to Nickel. Scandinavian Journal of Immunology 2005;62:289-296. (Link)

M„kitalo,B.; Andersson,M.; Arestrom,I.; Karlen,K.; Villinger,F.; Ansari,A.; Paulie,S.; Thorstensson,R.; Ahlborg,N.. ELISpot and ELISA analysis of spontaneous, mitogen-induced and antigen-specific cytokine production in cynomolgus and... Journal of Immunological Methods 2002;270:85-97. (Link)

Salmenpera,Pertteli; Hamalainen,Sammy; Hukkanen,Mika; Kankuri,Esko. Interferon-gamma induces C/EBPbeta expression and activity through MEK/ERK and p38 in T84 colon epithelial cells. Cell Physiology 2003;284:C1133-C1139. (Link)

Lawrence,B.Paige; Denison,Michael S.; Novak,Hermann; Vorderstrasse,Beth A.; Harrer,Nathalie; Neruda,Wolfgang; Reichel,Claudia; Woisetschlager,Maximilian. Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound. Blood 2008;112:1158-1165. (Link)

Minang,J.T.; Arestrom,I.; Zuber,B.; Jonsson,G.; Troye-Blomberg,M.; Ahlborg,N.. Nickel-induced IL-10 down-regulates Th1- but not Th2-type cytokine responses to the contact allergen nickel. Clinical and Experimental Immunology 2006;143:494-502. (Link)

Lehner,Manfred; Felzmann,Thomas; Clodi,Katharina; Holter,Wolfgang. Type I interferons in combination with bacterial stimuli induce apoptosis of monocyte-derived dendritic cells. Blood 2001;98:736-742. (Link)

Halary,Franck; Pitard,Vincent; Dlubek,Dorota; Krzysiek,Roman; de la Salle,Henri; Merville,Pierre; Dromer,Claire; Emilie,Dominique; Moreau,Jean Francois; Dechanet-Merville,Julie. Shared reactivity of V{delta}2neg {gamma}{delta} T cells against cytomegalovirus-infected cells and tumor intestinal epithelial cells. Journal of Experimental Medicine 2005;201:1567-1578. (Link)

Ettmayer,Peter; Mayer,Peter; Kalthoff,Frank; Neruda,Wolfgang; Harrer,Nathalie; Hartmann,Gabriella; Epstein,Michelle M.; Brinkmann,Volker; Heusser,Christoph; Woisetschlager,Maximilian. A Novel Low Molecular Weight Inhibitor of Dendritic Cells and B Cells Blocks Allergic Inflammation. American Journal of Respiratory and Critical Care Medicine 2006;173:599-606. (Link)

Lehner,Manfred; Stilper,Andrea; Morhart,Patrick; Holter,Wolfgang. Plasticity of dendritic cell function in response to prostaglandin E2 (PGE2) and interferon-{gamma} (IFN-{gamma}). Journal of Leukocyte Biology 2008;83:883-893. (Link)