Anti-Human IFN gamma APC

Description: The 4S.B3 monoclonal antibody reacts with interferon-gamma (IFN gamma). The 4S.B3 antibody is a neutralizing antibody. Human IFN gamma is a 17 kDa factor produced by activated T and NK cells and is an anti-viral and anti-parasitic cytokine. IFN gamma in synergy with other cytokines, such as TNF alpha, inhibits proliferation of normal and transformed cells. Immunomodulatory effects of IFN gamma are exerted on a wide range of cell types expressing the high affinity receptors for IFN gamma. Glycosylation of IFN gamma does not affect its biological activity.

References: Meager, A., S. Parti, et al. (1984). Detection of hybridomas secreting monoclonal antibodies to human gamma interferon using a rapid screening technique and specificity of certain monoclonal antibodies to gamma interferon. J Interferon Res 4(4): 619-25.