Description: The IFNb/A1 clone recognizes natural human IFN-beta and recombinants beta1a and beta1b. It is capable of neutralizing IFN-beta.
Interferon beta is synthesized and secreted by fibroblasts and many other cell types in response to pathogens. IFN?beta binding to type I interferon receptors induces the upregulation of IRF?7 and activation of Rnase L. IRF?7 can exert a positive feedback on IFN?beta production. RNase L cleaves both viral and cellular single stranded mRNA, thereby limiting viral replication and dissemination.